(S)-1-苄氧羰基六氢哒嗪-3-羧酸合成路线 （共 15 条）
反应条件
lithium hydroxide in tetrahydrofuran; water T=0°C; 3 h;
参考文献
Coats, Reed A.; Lee, Sheng-Lian; Davis, Kari A.; Patel, Kanu M.; Rhoads, Elaine K.; Howard, Michael H.
Journal of Organic Chemistry, 2004 , vol. 69, # 5 p. 1734 - 1737
反应条件
sodium hydroxide in toluene
参考文献
Chen; Goel; Hyun; Magano; Rubin
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1587 - 1592
反应条件
1: 85 percent / nBuLi / tetrahydrofuran / -78 °C 2: 99 percent / LDA; DMPU / -78 °C 3: 76 percent / LiOH / H2O / 0 °C 4: 40 percent / NaOH / H2O; toluene / 16 h / 20 °C / pH 9 - 10 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 5 p. 1734 - 1737
反应条件
1: 99 percent / LDA; DMPU / -78 °C 2: 76 percent / LiOH / H2O / 0 °C 3: 40 percent / NaOH / H2O; toluene / 16 h / 20 °C / pH 9 - 10 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 5 p. 1734 - 1737
反应条件
1: 76 percent / LiOH / H2O / 0 °C 2: 40 percent / NaOH / H2O; toluene / 16 h / 20 °C / pH 9 - 10 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 5 p. 1734 - 1737
反应条件
1: 90 percent / pyridine / CH2Cl2 / -30 - 20 °C 2: 84 percent / NaBH4, KH2PO4 / methanol; H2O / 22 - 32 °C 3: 100 percent / NEt3 / CH2Cl2 / 2 h / 0 °C 4: 1.) NaNO2, Ac2O, 2.) Zn, HOAc / 1.) HOAc, 0 deg C, 2.) 0 deg C, 3 h 5: 84 percent / NaH / dimethylformamide / 0.5 h / 0 °C 6: 1.) H2, 2.) 6N aq. HCl / 1.) Pd(0) / 1.) MeOH, RT, 1 bar, 4 h, 2.) MeOH, 110 deg C, 14 h View Scheme
参考文献
Synthesis, , # 2 p. 223 - 229
反应条件
1: 100 percent / NEt3 / CH2Cl2 / 2 h / 0 °C 2: 1.) NaNO2, Ac2O, 2.) Zn, HOAc / 1.) HOAc, 0 deg C, 2.) 0 deg C, 3 h 3: 84 percent / NaH / dimethylformamide / 0.5 h / 0 °C 4: 1.) H2, 2.) 6N aq. HCl / 1.) Pd(0) / 1.) MeOH, RT, 1 bar, 4 h, 2.) MeOH, 110 deg C, 14 h View Scheme
参考文献
Synthesis, , # 2 p. 223 - 229
反应条件
1: 84 percent / NaBH4, KH2PO4 / methanol; H2O / 22 - 32 °C 2: 100 percent / NEt3 / CH2Cl2 / 2 h / 0 °C 3: 1.) NaNO2, Ac2O, 2.) Zn, HOAc / 1.) HOAc, 0 deg C, 2.) 0 deg C, 3 h 4: 84 percent / NaH / dimethylformamide / 0.5 h / 0 °C 5: 1.) H2, 2.) 6N aq. HCl / 1.) Pd(0) / 1.) MeOH, RT, 1 bar, 4 h, 2.) MeOH, 110 deg C, 14 h View Scheme
参考文献
Synthesis, , # 2 p. 223 - 229
反应条件
1: 1.) NaNO2, Ac2O, 2.) Zn, HOAc / 1.) HOAc, 0 deg C, 2.) 0 deg C, 3 h 2: 84 percent / NaH / dimethylformamide / 0.5 h / 0 °C 3: 1.) H2, 2.) 6N aq. HCl / 1.) Pd(0) / 1.) MeOH, RT, 1 bar, 4 h, 2.) MeOH, 110 deg C, 14 h View Scheme
参考文献
Synthesis, , # 2 p. 223 - 229
反应条件
1: 84 percent / NaH / dimethylformamide / 0.5 h / 0 °C 2: 1.) H2, 2.) 6N aq. HCl / 1.) Pd(0) / 1.) MeOH, RT, 1 bar, 4 h, 2.) MeOH, 110 deg C, 14 h View Scheme
参考文献
Synthesis, , # 2 p. 223 - 229
