(2S)-3-(4-氨基苯基)-2-[(叔丁氧基羰基)氨基]丙酸甲酯合成路线 （共 6 条）
反应条件
ammonium chloride; zinc in methanol; water T=20 - 50°C;
参考文献
F. HOFFMANN-LA ROCHE AG; GOODNOW Jr., Robert, Alan; HAMILTON, Matthew, Michael; SIDDURI, Achyutharao
Patent: WO2013/110680 A1, 2013 ;
Location in patent: Page/Page column 66; 67 ;
反应条件
1: N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-L-alanine methyl ester With iodine; zinc in N,N-dimethyl-formamide T=20°C; Inert atmosphere; 2: para-amino-iodo-benzene With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0) in N,N-dimethyl-formamide T=20°C; Negishi coupling; Inert atmosphere;
参考文献
Ross, Andrew J.; Lang, Hannah L.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 1 p. 245 - 248
反应条件
1: methanol; CHCl3; hexane / 0 °C 2: 5.1 g / H2 / Pd/C / methanol; ethyl acetate / 23 °C / 1551.44 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 24 p. 6693 - 6702
反应条件
1: 9.66 g / NaOH / 2-methyl-propan-2-ol / 20 °C / pH 8 - 9 2: 63.2 percent / Et2O / 0.5 h / cooling 3: 94.4 percent / H2 / Pd/C / methanol / 2 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 86, # 10 p. 3326 - 3331
反应条件
1: 9.66 g / NaOH / 2-methyl-propan-2-ol / 20 °C / pH 8 - 9 2: 63.2 percent / Et2O / 0.5 h / cooling 3: 94.4 percent / H2 / Pd/C / methanol / 2 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 86, # 10 p. 3326 - 3331
反应条件
1: sodium carbonate 2: 10 palladium on activated charcoal; hydrogen View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 14 p. 6088 - 6091
