3,5-二甲基噻吩-2-羧酸合成路线 （共 13 条）
反应条件
chromium(VI) oxide; sulfuric acid; water in acetone
T=20°C; 6 h;
参考文献
Belen'kii; Gromova; Kolotaev; Nabatov; Krayushkin
Russian Chemical Bulletin, 2005 , vol. 54, # 5 p. 1208 - 1213
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=0°C; 1 h;
参考文献
Gould, Norman P.; Lee, Ta-Jyh
Journal of Organic Chemistry, 1980 , vol. 45, # 22 p. 4528 - 4530
反应条件
1: 3-methyl-2-thiophene-carboxylic acid With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene
T=0°C; 1.5 h;
2: methyl iodide in tetrahydrofuran; n-heptane; ethylbenzene
T=0°C; 2 h;
参考文献
Lin, Ronghui; Connolly, Peter J.; Huang, Shenlin; Wetter, Steven K.; Lu, Yanhua; Murray, William V.; Emanuel, Stuart L.; Gruninger, Robert H.; Fuentes-Pesquera, Angel R.; Rugg, Catherine A.; Middleton, Steven A.; Jolliffe, Linda K.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 13 p. 4208 - 4211
反应条件
in tetrahydrofuran; hexane
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5840917 A1, 1998 ;
反应条件
1: t-BuLi / diethyl ether / -70 °C
2: LDA / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Gould, Norman P.; Lee, Ta-Jyh
Journal of Organic Chemistry, 1980 , vol. 45, # 22 p. 4528 - 4530
反应条件
1: Jones reagent
2: LDA / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Gould, Norman P.; Lee, Ta-Jyh
Journal of Organic Chemistry, 1980 , vol. 45, # 22 p. 4528 - 4530
反应条件
1: 66 percent / POCl3 / 3 h / 70 - 75 °C
2: 55 percent / CrO3; H2O; H2SO4 / acetone / 6 h / 20 °C
View Scheme
参考文献
Belen'kii; Gromova; Kolotaev; Nabatov; Krayushkin
Russian Chemical Bulletin, 2005 , vol. 54, # 5 p. 1208 - 1213
反应条件
1: 50 percent / ethanol / Heating
2: 6N aq. KOH
View Scheme
参考文献
Alberola, Angel; Andres, Jose M.; Gonzalez, Alfonso; Pedrosa, Rafael; Pradanos, Pedro
Synthetic Communications, 1990 , vol. 20, # 16 p. 2537 - 2547
反应条件
1: Bildung ueber das Hydrazon
2: diethyl ether / anschliessendes Hydrolysieren
3: silver oxide
View Scheme
参考文献
Sice
Journal of Organic Chemistry, 1954 , vol. 19, p. 70,72
反应条件
n-butyllithium; tert.-butyl lithium
1) Ether, -70 deg C. 2) Room temp.; Multistep reaction;
参考文献
Gould, Norman P.; Lee, Ta-Jyh
Journal of Organic Chemistry, 1980 , vol. 45, # 22 p. 4528 - 4530
