4'-去甲氧基表鬼臼毒素合成路线 （共 24 条）
反应条件
1: 80 percent / boron trichloride / CH2Cl2 / 1 h / -70 - -65 °C 2: 94 percent / diethyl ether; methanol / 3 h / Ambient temperature 3: 1.) HBr, 2.) barium carbonate / 1.) dichloromethane, RT, 14 h, 2.) 1,2-dichloroethane, RT, overnight View Scheme
参考文献
Wang; Hu; Chen; Cheng; Lee
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 871 - 877
反应条件
1: HBr / CH2Cl2; diethyl ether / 0.75 h / 0 °C 2: 72 percent / Et3N, Bu4N(1+)*I(1-) / tetrahydrofuran / 6 h / 25 - 35 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 19 p. 3359 - 3362
反应条件
1: 80 percent / boron trichloride / CH2Cl2 / 1 h / -70 - -65 °C 2: 94 percent / diethyl ether; methanol / 3 h / Ambient temperature 3: 1.) HBr, 2.) barium carbonate / 1.) dichloromethane, RT, 14 h, 2.) 1,2-dichloroethane, RT, overnight View Scheme
参考文献
Wang; Hu; Chen; Cheng; Lee
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 871 - 877
反应条件
1: 80 percent / boron trichloride / CH2Cl2 / 1 h / -70 - -65 °C
2: 94 percent / diethyl ether; methanol / 3 h / Ambient temperature
3: 1.) HBr, 2.) barium carbonate / 1.) dichloromethane, RT, 14 h, 2.) 1,2-dichloroethane, RT, overnight
View Scheme
参考文献
Wang; Hu; Chen; Cheng; Lee
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 871 - 877
