4'-去甲氧基表鬼臼毒素 合成路线 （共 24 条）
反应条件
methanesulfonic acid; dl-methionine; trifluoroacetic acid T=40°C; 0.75 h;
参考文献
Guminski, Yves; Grousseaud, Martial; Cugnasse, Sandrine; Imbert, Thierry
→
反应条件
4375-07-9 5,8,8a,9-四氢-9-羟基-5-(3,4,5-三甲氧基苯基)-(5R,5aR,8aR,9S)-呋喃并[3',4':6,7]萘并[2,3-d]-1,3-二氧杂环戊烯-6(5aH)-酮
反应条件
1: With sodium iodide in dichloromethane 0.0833333 h; 2: With methanesulfonic acid in dichloromethane T=0 - 20°C; 3: With barium carbonate in dichloromethane; water; acetone T=0 - 20°C; 1 h;
参考文献
US2009/318675 A1, ;
反应条件
water; barium carbonate in acetone T=40°C; 4 h;
参考文献
Hansen; Jensen; Willumsen; Norskov-Lauritsen; Ebbesen; Nielsen; Buchardt
反应条件
barium carbonate in acetone T=20°C; Substitution; 0.5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 18 p. 2059 - 2062
反应条件
methanesulfonic acid; dimethylsulfide; trifluoroacetic acid 18 h;
参考文献
WO2005/100363 A1, ;
反应条件
barium carbonate in water; acetone T=40°C; 1.5 h;
参考文献
Tetrahedron Letters, , vol. 37, # 19 p. 3359 - 3362
反应条件
1: With molecular sieve; tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide in dichloromethane 2 h; 2: With tetrabutyl ammonium fluoride in tetrahydrofuran 0.333333 h;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 2 p. 593 - 603
反应条件
barium carbonate in water; acetone
参考文献
Tetrahedron Letters, , vol. 40, # 10 p. 1967 - 1970
反应条件
methanesulfonic acid; dl-methionine T=20°C; 1 h;
参考文献
Guminski, Yves; Grousseaud, Martial; Cugnasse, Sandrine; Imbert, Thierry
→
反应条件
4375-07-9 5,8,8a,9-四氢-9-羟基-5-(3,4,5-三甲氧基苯基)-(5R,5aR,8aR,9S)-呋喃并[3',4':6,7]萘并[2,3-d]-1,3-二氧杂环戊烯-6(5aH)-酮
反应条件
hydrogen bromide 1.) 15 min, 2.) RT, 20 h; Multistep reaction. Further byproducts given;
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 8 p. 1547 - 1550
