(S)-2-甲氧基-1-苯乙醇合成路线 （共 12 条）
反应条件
sodium tetrahydroborate; L-(+)-tartaric acid in tetrahydrofuran
T=-20°C; 69 h; other α- or β-functionalized ketones;
参考文献
Yatagai, Masanobu; Ohnuki, Takashi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 6 p. 1826 - 1828
反应条件
hydrogenchloride in tetrahydrofuran
22 h;
参考文献
Brunner; Rueckert
Monatshefte fur Chemie, 1998 , vol. 129, # 4 p. 339 - 354
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 4 h / |Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
3.1: tetrabutyl ammonium fluoride / acetonitrile
4.1: sodium hydride / tetrahydrofuran / 1 h
4.2: |Darkness
5.1: hydrogenchloride / tetrahydrofuran; water / 4 h
View Scheme
参考文献
Wu, Guang-Peng; Zu, Yu-Ping; Xu, Peng-Xiang; Ren, Wei-Min; Lu, Xiao-Bing
Chemistry - An Asian Journal, 2013 , vol. 8, # 8 p. 1854 - 1862
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
2.1: tetrabutyl ammonium fluoride / acetonitrile
3.1: sodium hydride / tetrahydrofuran / 1 h
3.2: |Darkness
4.1: hydrogenchloride / tetrahydrofuran; water / 4 h
View Scheme
参考文献
Wu, Guang-Peng; Zu, Yu-Ping; Xu, Peng-Xiang; Ren, Wei-Min; Lu, Xiao-Bing
Chemistry - An Asian Journal, 2013 , vol. 8, # 8 p. 1854 - 1862
反应条件
1.1: tetrabutyl ammonium fluoride / acetonitrile
2.1: sodium hydride / tetrahydrofuran / 1 h
2.2: |Darkness
3.1: hydrogenchloride / tetrahydrofuran; water / 4 h
View Scheme
参考文献
Wu, Guang-Peng; Zu, Yu-Ping; Xu, Peng-Xiang; Ren, Wei-Min; Lu, Xiao-Bing
Chemistry - An Asian Journal, 2013 , vol. 8, # 8 p. 1854 - 1862
反应条件
1.1: sodium hydride / tetrahydrofuran / 1 h
1.2: |Darkness
2.1: hydrogenchloride / tetrahydrofuran; water / 4 h
View Scheme
参考文献
Wu, Guang-Peng; Zu, Yu-Ping; Xu, Peng-Xiang; Ren, Wei-Min; Lu, Xiao-Bing
Chemistry - An Asian Journal, 2013 , vol. 8, # 8 p. 1854 - 1862
反应条件
hydrogenchloride in tetrahydrofuran; water
4 h;
参考文献
Wu, Guang-Peng; Zu, Yu-Ping; Xu, Peng-Xiang; Ren, Wei-Min; Lu, Xiao-Bing
Chemistry - An Asian Journal, 2013 , vol. 8, # 8 p. 1854 - 1862
反应条件
molecular sieve; lipase B from Candida antarctica in 1,4-dioxane
T=30°C; 163 h; Title compound not separated from byproducts;
参考文献
Garcia-Urdiales, Eduardo; Rebolledo, Francisca; Gotor, Vicente
Tetrahedron Asymmetry, 2001 , vol. 12, # 21 p. 3047 - 3052
反应条件
1: 1) TFA, 2) LiAlH4 / 1) 0 deg C, 22 h, r.t., 3 h, 2) Et2O, reflux, 14 h
2: 89 percent / KOH / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 97 percent / aq. HCl / tetrahydrofuran / 22 h
View Scheme
参考文献
Brunner; Rueckert
Monatshefte fur Chemie, 1998 , vol. 129, # 4 p. 339 - 354
反应条件
1: 89 percent / KOH / dimethylsulfoxide / 1.5 h / Ambient temperature
2: 97 percent / aq. HCl / tetrahydrofuran / 22 h
View Scheme
参考文献
Brunner; Rueckert
Monatshefte fur Chemie, 1998 , vol. 129, # 4 p. 339 - 354
