N-甲基-1-萘甲胺盐酸盐合成路线 （共 16 条）
反应条件
sodium hydroxide; sodium borohydride in methanol; ethyl acetate; toluene
参考文献
Lee, Tai-Au; Wang, Kyu-Jung; Kim, Hong-Bae; Kwon, Kyoung-Chan; Ku, Chang-Hoe
Patent: US2003/130530 A1, 2003 ;
反应条件
sodium hydroxide; sodium borohydride in ethyl acetate; isopropyl alcohol; toluene
参考文献
Lee, Tai-Au; Wang, Kyu-Jung; Kim, Hong-Bae; Kwon, Kyoung-Chan; Ku, Chang-Hoe
Patent: US2003/130530 A1, 2003 ;
反应条件
sodium hydroxide; sodium borohydride in ethyl acetate; isopropyl alcohol; toluene
参考文献
Lee, Tai-Au; Wang, Kyu-Jung; Kim, Hong-Bae; Kwon, Kyoung-Chan; Ku, Chang-Hoe
Patent: US2003/130530 A1, 2003 ;
反应条件
1: With sodium carbonate in water; N,N-dimethyl-formamide T=11 - 60°C; 6.25 h; 2: With hydrogenchloride in water pH=0.2; 0.5 h;
参考文献
SATYANARAYANA REDDY, Manne; RAMA SUBBA REDDY, Karamala
Patent: WO2007/96904 A2, 2007 ;
Location in patent: Page/Page column 22 ;
反应条件
1: With sodium carbonate in water T=77 - 83°C; 6 - 8 h; Industry scale; 2: With hydrogenchloride in water; toluene T=20 - 25°C; pH=0.5 - 1.5; 0.333333 h; Industry scale; Product distribution / selectivity;
参考文献
Kaspi, Joseph; Arad, Oded; Friedman, Oded; Manascu, Iosef; Fizitzki, Tamir; Danon, Edna
Patent: US2006/4230 A1, 2006 ;
Location in patent: Page/Page column 6; 10-11 ;
反应条件
1: 25 percent / triethylamine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH2Cl2 / 2 h / 20 °C
2: 31 percent / lithium aluminum hydride / tetrahydrofuran / 5 h / 20 °C
View Scheme
参考文献
Di Santo, Roberto; Costi, Roberta; Artico, Marino; Massa, Silvio; Musiu, Chiara; Milia, Carlo; Putzolu, Monica; La Colla, Paolo
Medicinal Chemistry Research, 1997 , vol. 7, # 2 p. 98 - 108
