4-氨基-2-三氟甲基苯甲腈合成路线 （共 41 条）
反应条件
1: C11H14O4; 4-amino-2-(trifluoromethyl)benzonitrile With 4-(N,N-dimethlyamino)pyridine; thionyl chloride in tetrahydrofuran T=20°C; 120 h; 2: acetic anhydride With pyridine in tetrahydrofuran Further stages.;
参考文献
Tetrahedron Letters, , vol. 48, # 6 p. 979 - 983
反应条件
1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.08 h / |Inert atmosphere; |Large scale 2.1: hydrogenchloride / toluene; ethyl acetate; water / 0.08 h / 20 - 25 °C 2.2: 76 - 78 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 12, # 6 p. 1146 - 1155
反应条件
thionyl chloride in tetrahydrofuran T=20°C; 120 h;
参考文献
Tetrahedron Letters, , vol. 48, # 6 p. 979 - 983
反应条件
1: 42 percent / thionyl chloride / N,N-dimethyl-acetamide / -10 - 20 °C 2: 94 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 29 p. 5905 - 5908
反应条件
1: With hydrogenchloride; sodium nitrite T=0°C; 0.333333 h; 2: With potassium iodide T=0 - 20°C; 4 h; Further stages.;
参考文献
Van Camp, Jennifer A.; Hu, Lain-Yen; Kostlan, Catherine; Lefker, Bruce; Li, Jie; Mitchell, Lorna; Wang, Zhi; Yue, Wen-Song; Carroll, Matthew; Dettling, Danielle; Du, Daniel; Pocalyko, David; Wade, Kimberly
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 20 p. 5529 - 5532
反应条件
thionyl chloride in tetrahydrofuran T=20°C; 120 h;
参考文献
Fujino, Aya; Asano, Masayoshi; Yamaguchi, Hitomi; Shirasaka, Naoki; Sakoda, Akiko; Ikunaka, Masaya; Obata, Rika; Nishiyama, Shigeru; Sugai, Takeshi
Tetrahedron Letters, 2007 , vol. 48, # 6 p. 979 - 983
反应条件
1: 42 percent / thionyl chloride / N,N-dimethyl-acetamide / -10 - 20 °C 2: 94 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 20 °C View Scheme
参考文献
James, Kenneth D; Ekwuribe, Nnochiri N
Tetrahedron, 2002 , vol. 58, # 29 p. 5905 - 5908
反应条件
1.1: potassium carbonate / 1,2-dichloro-ethane / 14 h / 20 °C 2.1: sodium nitrite / N,N-dimethyl-formamide / 14 h / 20 °C 3.1: iron; hydrogenchloride / isopropyl alcohol; ethanol; water / 1 h / 90 °C 4.1: potassium carbonate / 1,2-dichloro-ethane / 14 h 5.1: sodium nitrite / N,N-dimethyl-formamide / 14 h / 20 °C 6.1: N,N-dimethyl-formamide / 7 h / 110 °C 7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h 7.2: 2 h / 50 °C View Scheme
参考文献
Leonard, Matthew J.; Lingham, Anthony R.; Niere, Julie O.; Jackson, Neale R. C.; McKay, Peter G.; Huegel, Helmut M.
RSC Advances, 2014 , vol. 4, # 27 p. 14143 - 14148
反应条件
copper(I) bromide in aq HBr; water; sodium nitrite
参考文献
Endorecherche, Inc.
Patent: US2004/6134 A1, 2004 ;
US 20040006134 A1
反应条件
potassium carbonate in dichloromethane T=14 - 20°C; 1.5 h; Inert atmosphereLarge scale reaction;
参考文献
Li, Xun; Ng, Raymond A.; Zhang, Yongzheng; Russell, Ronald K.; Sui, Zhihua
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 652 - 655
