4-氨基-6-(三氟甲基)苯-1,3-二磺酰胺合成路线 （共 9 条）
反应条件
sodium hydroxide in water reflux, 2 h; room temperature, 20 h;
参考文献
Hennig; Moskalyk; Chatten; Chan
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 3 p. 317 - 319
参考文献
Journal of the American Chemical Society, , vol. 82, p. 1132 - 1135
反应条件
(i) ClSO3H, (heating), (ii) SOCl2, (iii) aq. NH3; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 25, p. 965 - 970
反应条件
C64H73O4P in dichloromethane T=20°C; 168 h; Inert atmosphereMolecular sieve; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 130, # 47 p. 15786 - 15787
反应条件
sodium hydroxide; iodine; potassium iodide T=0 - 4°C;
参考文献
Supuran, Claudiu T; Briganti, Fabrizio; Tilli, Silvia; Chegwidden; Scozzafava, Andrea
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 703 - 714
反应条件
sodium hydroxide; sodium hypochlorite T=25 - 30°C;
参考文献
Supuran, Claudiu T; Briganti, Fabrizio; Tilli, Silvia; Chegwidden; Scozzafava, Andrea
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 703 - 714
反应条件
hydrogenchloride in ethanol Heating;
参考文献
Klosa,J.; Voigt,H.
Journal fuer Praktische Chemie (Leipzig), 1962 , vol. 16, p. 264 - 276
反应条件
hydrogenchloride in N,N-dimethyl-formamide
参考文献
Craveri,F.; Zoni,G.
Bollettino Chimico Farmaceutico, 1961 , vol. 100, p. 956 - 971
参考文献
Close,W.J. et al.
Journal of the American Chemical Society, 1960 , vol. 82, p. 1132 - 1135
