4-苯基-2-羟甲基噻唑合成路线 （共 12 条）
反应条件
lithium aluminium tetrahydride in diethyl ether T=-40 - 20°C; 3.33 h; Inert atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00149 ;
反应条件
sodium tetrahydroborate in ethanol
参考文献
US6342497 B1, ;
Page column 32 ;
反应条件
hydrogenchloride in 1,4-dioxane
反应条件
1: ethanol 2: aqueous H2SO4 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 53, p. 1470,1472
反应条件
in diethyl ether; water; ethyl acetate
参考文献
US2013/289238 A1, ;
Page/Page column ;
参考文献
Journal of the American Chemical Society, , vol. 53, p. 1470,1472
参考文献
Journal of the American Chemical Society, , vol. 53, p. 1470,1472
反应条件
phosphorus tribromide in dichloromethane T=0 - 22°C; 4.2 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00150 ;
反应条件
sodium dichromate; acetic acid
参考文献
SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; JONES, Philip; XIE, Linghong
Patent: WO2011/150156 A2, 2011 ;
Location in patent: Page/Page column 114 ;
WO 2011/150156 A2
反应条件
1: Na2Cr2O7; acetic acid 2: AgNO3; aq.-ethanolic NaOH View Scheme
参考文献
Canas Rodriguez; Lopez Aparicio
Anales de la Real Sociedad Espanola de Fisica y Quimica, 1954 , vol. <B> 50, p. 609,614
