(1R,2R)-1,2-环己烷二甲醇合成路线 （共 17 条）
反应条件
1: With diisobutylaluminium hydride in toluene T=-5 - 20°C; 6 h; Inert atmosphere; 2: With hydrogenchloride; water in toluene T=-5 - 40°C; 13 h;
参考文献
RANBAXY LABORATORIES LIMITED; JAYACHANDRA, Suresh, Babu; GAHLOT, Udaibhan, Singh; SINGH, Tarun, Kumar; KHANDURI, Chandra, Has
Patent: WO2012/131606 A1, 2012 ;
Location in patent: Page/Page column 13 ;
反应条件
1: diethyl ether 2: LiAlH4 / diethyl ether View Scheme
参考文献
Tetrahedron, , vol. 21, p. 1701 - 1709
反应条件
lithium aluminium tetrahydride in diethyl ether 12 h; Heating;
参考文献
Jakovac, Ignac J.; Goodbrand, H. Bruce; Lok, Kar P.; Jones, J. Bryan
Journal of the American Chemical Society, 1982 , vol. 104, # 17 p. 4659 - 4665
反应条件
1: 86 percent / H2 / Pd/C / methanol 2: 34 percent / NaOH / H2O / 192 h / 130 °C 3: 80 percent / LiAlH4 / diethyl ether / 12 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 104, # 17 p. 4659 - 4665
反应条件
1: 83 percent / NAD+, FMN, pH 9, HLADH, NaOH, glycine / 48 h / 20 °C 2: 86 percent / H2 / Pd/C / methanol 3: 34 percent / NaOH / H2O / 192 h / 130 °C 4: 80 percent / LiAlH4 / diethyl ether / 12 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 104, # 17 p. 4659 - 4665
反应条件
1: 80 percent / NAD+, FMN, pH 9, HLADH, NaOH, glycine / Ambient temperature 2: 34 percent / NaOH / H2O / 192 h / 130 °C 3: 80 percent / LiAlH4 / diethyl ether / 12 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 104, # 17 p. 4659 - 4665
反应条件
1: 34 percent / NaOH / H2O / 192 h / 130 °C 2: 80 percent / LiAlH4 / diethyl ether / 12 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 104, # 17 p. 4659 - 4665
反应条件
1: LiAlH4 2: 80 percent / NAD+, FMN, pH 9, HLADH, NaOH, glycine / Ambient temperature 3: 34 percent / NaOH / H2O / 192 h / 130 °C 4: 80 percent / LiAlH4 / diethyl ether / 12 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 104, # 17 p. 4659 - 4665
反应条件
1.1: ethanol / 6.5 h / -70 - 20 °C / Resolution of racemate 2.1: hydrogenchloride / water 3.1: sulfuric acid / 18 h / 40 °C 4.1: diisobutylaluminium hydride / toluene / 6 h / -5 - 20 °C / Inert atmosphere 4.2: 13 h / -5 - 40 °C View Scheme
反应条件
1: With hydrogen; palladium on activated charcoal 2: With lithium aluminium tetrahydride
参考文献
Journal of Heterocyclic Chemistry, , vol. 39, # 5 p. 1049 - 1054
