(1R)-1,4-脱水-2-脱氧-1-(1,3-二甲基-2,4-二氧代-1,2,3,4-四氢-5-嘧啶基)-D-赤式-戊糖醇合成路线 （共 25 条）
反应条件
lithium borohydride in tetrahydrofuran
T=-78°C; 1.5 h;
参考文献
Cheng, Jane Chi-Ya; Hacksell, Uli; Daves, G. Doyle
Journal of Organic Chemistry, 1986 , vol. 51, # 16 p. 3093 - 3098
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
0.5 h;
参考文献
Cheng, Jane Chi-Ya; Hacksell, Uli; Daves, G. Doyle
Journal of Organic Chemistry, 1986 , vol. 51, # 16 p. 3093 - 3098
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
参考文献
Pankiewicz, Krzysztof; Matsuda, Akira; Watanabe, Kyoichi A.
Journal of Organic Chemistry, 1982 , vol. 47, # 3 p. 485 - 488
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in toluene
Heating;
参考文献
Pankiewicz; Watanabe; Takayanagi; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 6 p. 1703 - 1710
反应条件
1: 69 percent / dimethylformamide / 4 h / Ambient temperature
2: 65 percent / 2,2'-azobis(2-methylpropionitryle), n-Bu3SnH / toluene / 1 h / Heating
3: 75 percent / n-Bu4NF / tetrahydrofuran
View Scheme
参考文献
Pankiewicz, Krzysztof; Matsuda, Akira; Watanabe, Kyoichi A.
Journal of Organic Chemistry, 1982 , vol. 47, # 3 p. 485 - 488
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in toluene
Heating;
参考文献
Pankiewicz; Watanabe; Takayanagi; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 6 p. 1703 - 1710
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in toluene
Heating;
参考文献
Pankiewicz; Watanabe; Takayanagi; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 6 p. 1703 - 1710
反应条件
1: 1.) Pd(OAc)2, 2.) Na2CO3 / 1.) acetonitrile, RT, 42 h, 2.) acetonitrile, 65 deg C, 1 h
2: 21 percent / LiBH4 / tetrahydrofuran / 1.5 h / -78 °C
View Scheme
参考文献
Cheng, Jane Chi-Ya; Hacksell, Uli; Daves, G. Doyle
Journal of Organic Chemistry, 1986 , vol. 51, # 16 p. 3093 - 3098
反应条件
1: 1.) Pd(OAc)2, 2.) Na2CO3 / 1.) acetonitrile, RT, 42 h, 2.) acetonitrile, 65 deg C, 1 h
2: 21 percent / LiBH4 / tetrahydrofuran / 1.5 h / -78 °C
View Scheme
参考文献
Cheng, Jane Chi-Ya; Hacksell, Uli; Daves, G. Doyle
Journal of Organic Chemistry, 1986 , vol. 51, # 16 p. 3093 - 3098
反应条件
1: 1.) Pd(OAc)2, 2.) Na2CO3 / 1.) acetonitrile, 2 h, 2.) acetonitrile, 21 h
2: 86 percent / tetrabutylammonium fluoride, AcOH / tetrahydrofuran / 0.5 h / -78 °C
3: 27 percent / aq.NaBH4 / methanol / 0.5 h / 0 °C
4: 94 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h
View Scheme
参考文献
Cheng, Jane Chi-Ya; Hacksell, Uli; Daves, G. Doyle
Journal of Organic Chemistry, 1986 , vol. 51, # 16 p. 3093 - 3098
