3-乙酰基-2-氯-1-甲基吲哚合成路线 （共 8 条）
反应条件
sodium azide in dimethyl sulfoxide T=120°C; 0.05 h;
参考文献
Becher, Jan; Joergensen, Per Lauge; Pluta, Krystian; Krake, Niels J.; Faelt-Hansen, Birgitte
Journal of Organic Chemistry, 1992 , vol. <7> 57, p. 2127 - 2134
反应条件
1: in tetrahydrofuran
2: With N-methyl-2-indolinone; tetrapropylammonium perruthennate
Further stages.;
参考文献
Deng; Konopelski
Organic letters, 2001 , vol. 3, # 19 p. 3001 - 3004
反应条件
NaH in tetrahydrofuran; water
参考文献
Novo Nordisk A/S
Patent: US5783575 A1, 1998 ;
US 5783575 A
Title/Abstract Full Text Show Details
Novo Nordisk A/S
Patent: US5536721 A1, 1996 ;
US 5536721 A
反应条件
potassium carbonate in acetone
3 h; Heating;
参考文献
Monge; Palop; Ramirez; Font; Fernandez-Alvarez
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 2 p. 179 - 188
反应条件
diethylaluminium chloride in hexane; dichloromethane
T=0°C; Friedel-Crafts acylation; 0.5 h; Inert atmosphere;
参考文献
Liegault, Benoit; Petrov, Ivan; Gorelsky, Serge I.; Fagnou, Keith
Journal of Organic Chemistry, 2010 , vol. 75, # 4 p. 1047 - 1060
反应条件
1.1: 97 percent / NaH; KH / tetrahydrofuran / Heating
2.1: tetrahydrofuran
2.2: 96 percent / TPAP; NMO
View Scheme
参考文献
Deng; Konopelski
Organic letters, 2001 , vol. 3, # 19 p. 3001 - 3004
反应条件
1: 79 percent / POCl3 / CHCl3 / 5 h / Heating
2: 70 percent / K2CO3 / acetone / 3 h / Heating
View Scheme
参考文献
Monge; Palop; Ramirez; Font; Fernandez-Alvarez
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 2 p. 179 - 188
反应条件
diethylaluminium chloride in hexane; dichloromethane
T=0°C; 0.5 h; Inert atmosphere;
参考文献
Liegault, Benoit; Petrov, Ivan; Gorelsky, Serge I.; Fagnou, Keith
Journal of Organic Chemistry, 2010 , vol. 75, # 4 p. 1047 - 1060
