9-氯-2,7-二甲氧基吖啶合成路线 （共 7 条）
反应条件
trichlorophosphate
T=140°C;
参考文献
I.G.Farbenind.
Patent: DE632224 , 1934 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 539
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Kshatriya et al.
Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1946 , vol. 15/A, p. 42
反应条件
trichlorophosphate
T=120°C;
参考文献
Cuny, Gregory D.; Robin, Maxime; Ulyanova, Natalia P.; Patnaik, Debasis; Pique, Valerie; Casano, Gilles; Liu, Ji-Feng; Lin, Xiangjie; Xian, Jun; Glicksman, Marcie A.; Stein, Ross L.; Higgins, Jonathan M.G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3491 - 3494
反应条件
1: Cu, K2CO3 / 3-methyl-butan-1-ol / 4 h / Heating
2: POCl3 / 2 h / Heating
View Scheme
参考文献
Wysocka-Skrzela, Barbara; Cholody, Wieslaw M.; Ledochowski, Andrzej
Polish Journal of Chemistry, 1981 , vol. 55, # 10 p. 2211 - 2214
反应条件
1: Cu, K2CO3 / 3-methyl-butan-1-ol / 4 h / Heating
2: POCl3 / 2 h / Heating
View Scheme
参考文献
Wysocka-Skrzela, Barbara; Cholody, Wieslaw M.; Ledochowski, Andrzej
Polish Journal of Chemistry, 1981 , vol. 55, # 10 p. 2211 - 2214
反应条件
1: trichlorophosphate / toluene-4-sulfonic acid / 120 °C
2: sulfuric acid / 120 °C
3: tetraphosphorus decasulfide; N,N'-dimethyl-N,N'-propyleneurea / 95 °C
4: phenol / 80 °C
5: trichlorophosphate / 120 °C
View Scheme
参考文献
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; UNIVERSITY PAUL CEZANNE MARSEILLE III/AIX; HIGGINS, Jonathan; CUNY, Gregory D.; GLICKSMAN, Marcie; PATNAIK, Debasis; ROBIN, Maxime; STEIN, Ross L.; XIAN, Jun
Patent: WO2011/127406 A2, 2011 ;
WO 2011/127406 A2
反应条件
1: tetraphosphorus decasulfide; N,N'-dimethyl-N,N'-propyleneurea / 95 °C
2: phenol / 80 °C
3: trichlorophosphate / 120 °C
View Scheme
参考文献
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; UNIVERSITY PAUL CEZANNE MARSEILLE III/AIX; HIGGINS, Jonathan; CUNY, Gregory D.; GLICKSMAN, Marcie; PATNAIK, Debasis; ROBIN, Maxime; STEIN, Ross L.; XIAN, Jun
Patent: WO2011/127406 A2, 2011 ;
WO 2011/127406 A2
反应条件
1: phenol / 80 °C
2: trichlorophosphate / 120 °C
View Scheme
参考文献
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; UNIVERSITY PAUL CEZANNE MARSEILLE III/AIX; HIGGINS, Jonathan; CUNY, Gregory D.; GLICKSMAN, Marcie; PATNAIK, Debasis; ROBIN, Maxime; STEIN, Ross L.; XIAN, Jun
Patent: WO2011/127406 A2, 2011 ;
WO 2011/127406 A2
