1-(2,4-二羟基-3-丙基苯基)-2,2,2-三氟乙酮合成路线 （共 6 条）
反应条件
aluminium trichloride in 1,2-dichloro-ethane
参考文献
Karl-Thomae
Patent: BE853558DE2616479 , 19771977 ;
Chem.Abstr., 1978 , vol. 88, # 37429
反应条件
hydrogen; palladium on activated charcoal in various solvent(s)
P=760 Torr;
参考文献
Santini, Conrad; Berger, Gregory D.; Han, Wei; Mosley, Ralph; MacNaul, Karen; Berger, Joel; Doebber, Thomas; Wu, Margaret; Moller, David E.; Tolman, Richard L.; Sahoo, Soumya P.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 7 p. 1277 - 1280
反应条件
1: Cs2CO3 / dimethylformamide / 20 °C
2: 1,2-dichloro-benzene / Heating
3: 100 percent / H2 / 5 percent Pd/C / various solvent(s) / 760 Torr
View Scheme
参考文献
Santini, Conrad; Berger, Gregory D.; Han, Wei; Mosley, Ralph; MacNaul, Karen; Berger, Joel; Doebber, Thomas; Wu, Margaret; Moller, David E.; Tolman, Richard L.; Sahoo, Soumya P.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 7 p. 1277 - 1280
反应条件
1: 70 percent / BBr3 / CH2Cl2 / 1) -30 deg C, 2.5 h, 2) -30 deg C to rt, overnight
View Scheme
参考文献
Brown; Bersntein; Cronk; Dossett; Hebbel; Maduskuie Jr.; Shapiro; Vacek; Yee; Willard; Krell; Snyder
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 807 - 826
反应条件
1: 1)nBuLi / 1) THF, hexane, a) -25 deg C, 3 h, b) -5 deg C, 0.5 h, 2) THF, -5 deg C to rt, overnight
2: 70 percent / BBr3 / CH2Cl2 / 1) -30 deg C, 2.5 h, 2) -30 deg C to rt, overnight
View Scheme
参考文献
Brown; Bersntein; Cronk; Dossett; Hebbel; Maduskuie Jr.; Shapiro; Vacek; Yee; Willard; Krell; Snyder
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 807 - 826
反应条件
Yield given. Multistep reaction;
参考文献
Brown; Bersntein; Cronk; Dossett; Hebbel; Maduskuie Jr.; Shapiro; Vacek; Yee; Willard; Krell; Snyder
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 807 - 826
