反应条件
1.1: 4-(N,N-dimethlyamino)pyridine / anhydrous propionitrile / 0.17 h / 20 °C / Large scale reaction
1.2: 20 °C / Large scale reaction
2.1: zirconium tetrachloride / tetrahydrofuran / -5 - 0 °C / Inert atmosphere; Large scale reaction
2.2: -5 - 0 °C / Inert atmosphere; Large scale reaction
3.1: potassium hydroxide / 3-methyl pentan-3-ol / 18 h / 120 °C
4.1: boron tribromide / dichloromethane / 0 - 20 °C
View Scheme
参考文献
Dillon, Barry R.; Roberts, Dannielle F.; Entwistle, David A.; Glossop, Paul A.; Knight, Craig J.; Laity, Daniel A.; James, Kim; Praquin, Celine F.; Strang, Ross S.; Watson, Christine A. L.
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 195 - 203
