1-甲基 3-氧代哌啶-1,4-二羧酸-4-乙酯合成路线 （共 5 条）
反应条件
potassium carbonate; Pd-C in ethanol; water
参考文献
H. Lundbeck and Co. A/S
Patent: US4278676 A1, 1981 ;
反应条件
potassium carbonate in water
T=0 - 20°C; 1.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/20222 A1, 2008 ;
Location in patent: Page/Page column 93-94 ;
WO 2008/020222 A1
反应条件
potassium tert-butylate in toluene
1 h;
参考文献
Knight, David W.; Lewis, Neil; Share, Andrew C.; Haigh, David
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3673 - 3683
反应条件
1: 70 percent / Et3N / CH2Cl2
2: 51 percent / t-BuOK / toluene / 1 h
View Scheme
参考文献
Knight, David W.; Lewis, Neil; Share, Andrew C.; Haigh, David
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3673 - 3683
反应条件
sodium hydroxide; hydroxylamine
T=0 - 5°C; 1 h;
参考文献
Jacobsen; Kolind-Andersen; Christensen
Canadian Journal of Chemistry, 1984 , vol. 62, # 10 p. 1940 - 1944
