4-氰基-3-羟基苯甲酸甲酯合成路线 （共 11 条）
参考文献
Monatshefte fuer Chemie, , vol. 97, p. 570 - 578
反应条件
tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide)
T=80°C; 4 h;
参考文献
MacTough, Suzanne C.; Desolms, S. Jane; Shaw, Anthony W.; Abrams, Marc T.; Ciccarone, Terrence M.; Davide, Joseph P.; Hamilton, Kelly A.; Hutchinson, John H.; Koblan, Kenneth S.; Kohl, Nancy E.; Lobell, Robert B.; Robinson, Ronald G.; Graham, Samuel L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1257 - 1260
反应条件
sodium carbonate; palladium diacetate in dimethyl amine
T=20 - 120°C; 22 h;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 392 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
参考文献
Merck and Co., Inc.
Patent: US6387903 B1, 2002 ;
US 6387903 B1
反应条件
formic acid; hydroxylamine hydrochloride; sodium formate
14 h; Heating / reflux;
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: EP1489078 A1, 2004 ;
Location in patent: Page 195-196 ;
EP 1489078 A1
参考文献
Matter, Hans; Will, David W.; Nazare, Marc; Schreuder, Herman; Laux, Volker; Wehner, Volkmar
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3290 - 3312
反应条件
1.1: 96 percent / HCl / 5 h / 20 °C
2.1: HCl; NaNO2 / tetrahydrofuran / 0.33 h / 0 °C
2.2: 14 percent / KI / tetrahydrofuran / 0.75 h
3.1: 83 percent / Pd(Ph3P)4 / dimethylformamide / 1 h / 100 °C
View Scheme
参考文献
MacTough, Suzanne C.; Desolms, S. Jane; Shaw, Anthony W.; Abrams, Marc T.; Ciccarone, Terrence M.; Davide, Joseph P.; Hamilton, Kelly A.; Hutchinson, John H.; Koblan, Kenneth S.; Kohl, Nancy E.; Lobell, Robert B.; Robinson, Ronald G.; Graham, Samuel L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1257 - 1260
反应条件
1.1: HCl; NaNO2 / tetrahydrofuran / 0.33 h / 0 °C
1.2: 14 percent / KI / tetrahydrofuran / 0.75 h
2.1: 83 percent / Pd(Ph3P)4 / dimethylformamide / 1 h / 100 °C
View Scheme
参考文献
MacTough, Suzanne C.; Desolms, S. Jane; Shaw, Anthony W.; Abrams, Marc T.; Ciccarone, Terrence M.; Davide, Joseph P.; Hamilton, Kelly A.; Hutchinson, John H.; Koblan, Kenneth S.; Kohl, Nancy E.; Lobell, Robert B.; Robinson, Ronald G.; Graham, Samuel L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1257 - 1260
反应条件
bubbling air in water
T=20°C; 12 h; Irradiation; Product distribution;
参考文献
Yamada, Sachiko; Hokari, Hajime; Akasaka, Shinji; Iwamura, Michiko
Chemistry Letters, 1999 , # 3 p. 197 - 198
参考文献
Wessely,F.; Grossa,M.
Monatshefte fuer Chemie, 1966 , vol. 97, p. 570 - 578
