2-甲氧基-6-甲基苯甲酸乙酯合成路线 （共 20 条）
反应条件
potassium carbonate in acetone Heating;
参考文献
Hauser, Frank M.; Pogany, Stefano A.
Synthesis, 1980 , # 10 p. 814 - 815
反应条件
potassium carbonate in acetone 25 h; Heating;
参考文献
Hamada; Hara; Kawai; Kohno; Shioiri
Tetrahedron, 1991 , vol. 47, # 40 p. 8635 - 8652
参考文献
Schnur; Morville
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 770 - 778
参考文献
Tetrahedron, , vol. 44, # 18 p. 5745 - 5760
反应条件
sodium hydroxide; bromine; sodium acetate; acetic acid; P2 O5; dichloromethane in ethanol; water
参考文献
American Cyanamid Company
Patent: US5922905 A1, 1999 ;
反应条件
sodium hydroxide; bromine in tetrachloromethane; ethanol; dichloromethane; water
参考文献
American Cyanamid Company
Patent: US5922905 A1, 1999 ;
反应条件
boron tribromide in dichloromethane T=-78°C; 0.5 h;
参考文献
Journal of the American Chemical Society, , vol. 127, # 24 p. 8872 - 8888
反应条件
1: N-bromosuccinimide, benzoyl peroxide / CCl4 / Heating; Irradiation 2: 9percent HCl / acetic acid / 12 h / Heating 3: 72 percent / p-toluenesulfonic acid / benzene / 3 h / Heating 4: 98 percent / 30percent H2O2 / acetic acid / 1) RT, 2) reflux; m-chloroperbenzoic acid View Scheme
参考文献
Hauser, Frank M.; Rhee, Richard P.
Journal of Organic Chemistry, 1980 , vol. 45, # 15 p. 3061 - 3068
反应条件
1: 2-Methoxy-6-methylbenzoic acid ethyl ester With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.25 h; 2: acrylic acid methyl ester in tetrahydrofuran T=0°C; 5 h; Further stages.;
参考文献
Yang, Rui-Yang; Kizer, Darin; Wu, Hui; Volckova, Erika; Miao, Xiu-Sheng; Ali, Syed M.; Tandon, Manish; Savage, Ronald E.; Chan, Thomas C.K.; Ashwell, Mark A.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 10 p. 5635 - 5643
反应条件
1: With sodium hydroxide; water in ethanol 24 h; Heating / reflux; 2: With hydrogenchloride in water pH=4;
参考文献
RESVERLOGIX CORP.; JOHANSSON, Jan, O.; HANSEN, Henrik, C.; CHIACCHIA, Fabrizio, S.; WONG, Norman, C.W.
Patent: WO2007/16525 A2, 2007 ;
Location in patent: Page/Page column 108-112 ;
WO 2007/016525 A2
