5-硝基-2-(三氟甲基)-1,2-二氢嘧啶-4,6-二醇合成路线 （共 4 条）
反应条件
1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; phosphoric acid / 20 - 45 °C / Inert atmosphere 2: acetic acid; iron / 1.25 h / 50 °C View Scheme
参考文献
Deninno, Michael P.; Wright, Stephen W.; Etienne, John B.; Olson, Thanh V.; Rocke, Benjamin N.; Corbett, Jeffrey W.; Kung, Daniel W.; Dirico, Kenneth J.; Andrews, Kim M.; Millham, Michele L.; Parker, Janice C.; Esler, William; Van Volkenburg, Maria; Boyer, David D.; Houseknecht, Karen L.; Doran, Shawn D.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5721 - 5726
反应条件
nitric acid
T=4 - 6°C; 1.5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/136442 A1, 2006 ;
Location in patent: Page/Page column 26-27 ;
WO 2006/136442 A1
反应条件
phosphoric acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate
T=20 - 45°C; Inert atmosphere;
参考文献
Deninno, Michael P.; Wright, Stephen W.; Etienne, John B.; Olson, Thanh V.; Rocke, Benjamin N.; Corbett, Jeffrey W.; Kung, Daniel W.; Dirico, Kenneth J.; Andrews, Kim M.; Millham, Michele L.; Parker, Janice C.; Esler, William; Van Volkenburg, Maria; Boyer, David D.; Houseknecht, Karen L.; Doran, Shawn D.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5721 - 5726
反应条件
trichlorophosphate
T=120°C; 3.5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/136442 A1, 2006 ;
Location in patent: Page/Page column 26 ;
WO 2006/136442 A1
