3-(2-溴苯基)丙烷-1-胺合成路线 （共 13 条）
反应条件
1: 49 percent / Et3N / CH2Cl2 / 2 h 2: 43 percent / Cs2CO3, tris(dibenzylideneacetone)dipalladium(0), tri-(2-furyl)phosphine / toluene / 21 h / 110 °C View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
potassium phosphate; o-(OH)C6H4CONEt2; anhydrous copper acetate in N,N-dimethyl-formamide T=40°C; 18 h;
参考文献
Kwong, Fuk Yee; Buchwald, Stephen L.
Organic Letters, 2003 , vol. 5, # 6 p. 793 - 796
反应条件
1: With copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in toluene T=110°C; 23 h; 2: With acetic acid in tetrahydrofuran T=60°C; 4 h;
参考文献
Journal of the American Chemical Society, , vol. 126, # 11 p. 3529 - 3533
反应条件
palladium diacetate; triphenylphosphine
参考文献
Meyers, A. I.; Hutchings, Richard H.
Tetrahedron, 1993 , vol. 49, # 9 p. 1807 - 1820
反应条件
1: 30 percent / PPh3, Pd(OAc)2 2: 81 percent / lithium aluminium hydride / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Meyers, A. I.; Hutchings, Richard H.
Tetrahedron, 1993 , vol. 49, # 9 p. 1807 - 1820
反应条件
sodium tetrahydroborate; acetic acid in 1,4-dioxane
T=0°C; Inert atmosphereReflux;
参考文献
Balieu, Sebastien; Toutah, Krimo; Carro, Laura; Chamoreau, Lise-Marie; Rousseliere, Helene; Courillon, Christine
Tetrahedron Letters, 2011 , vol. 52, # 22 p. 2876 - 2880
反应条件
lithium aluminium tetrahydride; aluminium trichloride in diethyl ether
18 h;
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
1: SOCl2
2: NH4OH
3: NaBH4, HOAc
View Scheme
参考文献
Meyers, A. I.; Hutchings, Richard H.
Tetrahedron, 1993 , vol. 49, # 9 p. 1807 - 1820
反应条件
1: 99 percent / sodium bicarbonate, tetra-n-butyl ammonium chloride, palladium acetate / dimethylformamide / 48 h / 40 °C
2: 88 percent / NaBH4 / 1,2-dimethoxy-ethane; methanol / 15 h / 70 °C
3: 84 percent / AlCl3, LiAlH4 / diethyl ether / 18 h
View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
1: 88 percent / NaBH4 / 1,2-dimethoxy-ethane; methanol / 15 h / 70 °C
2: 84 percent / AlCl3, LiAlH4 / diethyl ether / 18 h
View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
