potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide T=80°C; 41 h;

1,10-phenanthroline; di-tert-butyl peroxide; copper diacetate; sodium acetate; sodium t-butanolate in 1,2-dichloro-ethane T=80°C; 6.03333 h; Inert atmosphereMolecular sieve;

1.1: K2CO3 / dimethylsulfoxide 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 35 percent / iodine / tetrahydrofuran; hexane / -78 - 20 °C 3.1: 37 percent / cuprous iodide; potassium fluoride / dimethylformamide; 1-methyl-pyrrolidin-2-one / 41 h / 80 °C View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 35 percent / iodine / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 37 percent / cuprous iodide; potassium fluoride / dimethylformamide; 1-methyl-pyrrolidin-2-one / 41 h / 80 °C View Scheme