3-(4-氟苯基)-1,2-恶唑合成路线 （共 8 条）
反应条件
1: thiophenol With lithium diisopropyl amide in tetrahydrofuran; hexane T=0°C; 0.166667 h; Inert atmosphere; 2: 3-(p-fluorophenyl)isoxazole in tetrahydrofuran; hexane T=-98°C; 1.01667 h; Inert atmosphere;
参考文献
Synthesis, , # 18 p. 3195 - 3203
反应条件
1: thiophenol With lithium diisopropyl amide in tetrahydrofuran; hexane T=0°C; 0.166667 h; Inert atmosphere; 2: 3-(p-fluorophenyl)isoxazole in tetrahydrofuran; hexane T=-98°C; 1.01667 h; Inert atmosphere;
参考文献
Synthesis, , # 18 p. 3195 - 3203
反应条件
sodium methylate in methanol
T=20°C; 3 h;
参考文献
Vitale, Paola; Di Nunno, Leonardo; Scilimati, Antonio
Synthesis, 2010 , # 18 p. 3195 - 3203
反应条件
1: 4-fluorobezaldoxime With N-chloro-succinimide in chloroform
T=20°C; 0.333333 h;
2: polystyrene-supported vinyl selenide With triethylamine in dichloromethane
T=20°C; 12 h;
3: With dihydrogen peroxide in tetrahydrofuran
T=20°C; 0.5 h; Further stages.;
参考文献
Sheng, Shou-Ri; Xin, Qin; Liu, Xiao-Ling; Sun, Wu-Kang; Guo, Rui; Huang, Xian
Synthesis, 2006 , # 14 p. 2293 - 2296
反应条件
pyridine; hydroxylamine hydrochloride in ethanol
T=78°C; 16 h;
参考文献
Rosa, Fernanda A.; Machado, Pablo; Bonacorso, Helio G.; Zanatta, Nilo; Martins, Marcos A. P.
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 3 p. 879 - 885
反应条件
1: With triethylamine in chloroform
T=20°C; 12 h;
2: With dihydrogen peroxide in chloroform
T=20°C; 0.333333 h;
参考文献
Sheng, Shou-Ri; Liu, Xiao-Ling; Xu, Qu; Song, Cai-Sheng
Synthesis, 2003 , # 18 p. 2763 - 2764
反应条件
1.1: N-chlorosuccinimide / CHCl3 / 0.33 h / 20 °C
2.1: Et3N / CHCl3 / 12 h / 20 °C
2.2: 267 mg / aq. H2O2 / CHCl3 / 0.33 h / 20 °C
View Scheme
参考文献
Sheng, Shou-Ri; Liu, Xiao-Ling; Xu, Qu; Song, Cai-Sheng
Synthesis, 2003 , # 18 p. 2763 - 2764
反应条件
1: With triethylamine in trichloroethane, 1,1,2-
0.5 h; Heating;
2: With sodium hydroxide
0.5 h; Heating;
参考文献
Schofield, Mark H.; Sorel, Marie-Adele; Manalansan, Ryan J.; Richardson, David P.; Markgraf, J. Hodge
Magnetic Resonance in Chemistry, 2006 , vol. 44, # 9 p. 851 - 855
