[(1R)-2-氯-1-(羟基甲基)乙基]-氨基甲酸叔丁酯合成路线 （共 4 条）
反应条件
1.1: 95 percent / Hunig's base / CH2Cl2 / 18 h / 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C 2.2: lithium naphthalenide / tetrahydrofuran; hexane / 2 h / -78 °C 2.3: tetrahydrofuran; hexane / -78 - -40 °C 3.1: 102 mg / diethyl ether; methanol; toluene / 0 °C 4.1: HCl / methanol / 3 h / 20 °C 4.2: 50 percent / CSA / benzene / 80 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 13 p. 3403 - 3417
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; ethanol
T=0 - 20°C; 4 h; Inert atmosphere;
2: With water; sodium hydrogencarbonate in tetrahydrofuran; ethanol
参考文献
MERCK CANADA INC.; MORADEI, Oscar, M.; CRANE, Sheldon; MCKAY, Daniel, J.; LEBRUN, Marie-Eve; TRUONG, Vouy Linh
Patent: WO2012/55034 A1, 2012 ;
Location in patent: Page/Page column 65-66 ;
WO 2012/055034 A1
反应条件
1: 84 percent / Ph3P; hexachloroethane / CH2Cl2 / 2 h / 20 °C
2: 81 percent / LiBH4 / ethanol; tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Kenworthy, Martin N.; Kilburn, John Paul; Taylor, Richard J. K.
Organic Letters, 2004 , vol. 6, # 1 p. 19 - 22
反应条件
1.1: AcCl
1.2: 100 percent / Et3N
2.1: 84 percent / Ph3P; hexachloroethane / CH2Cl2 / 2 h / 20 °C
3.1: 81 percent / LiBH4 / ethanol; tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Kenworthy, Martin N.; Kilburn, John Paul; Taylor, Richard J. K.
Organic Letters, 2004 , vol. 6, # 1 p. 19 - 22
