1-[4-(苯磺基）苯基]乙酮合成路线 （共 17 条）
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C 2.1: tetrahydrofuran; diethyl ether / 0.5 h / 60 °C / |Microwave irradiation 2.2: 0.5 h / 100 °C / |Microwave irradiation View Scheme
反应条件
diethyl ether; benzene Erwaermen des Reaktionsgemisches mit wss. H2SO4;
参考文献
Journal of the Chemical Society, , p. 601
反应条件
in chloroform T=20°C; 48 h; different sulphide/oxidizer ratio; Product distributionMechanism;
参考文献
Journal of Chemical Research, Miniprint, , # 6 p. 2201 - 2214
反应条件
sodium hypochlorite in ethanol T=60°C; 2 h;
参考文献
Sjogren, Eric B.; Rider, Michael A.; Nelson, Peter H.; Bingham, Stanford; Poulton, Anthony L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3295 - 3301
反应条件
(i) iPrOH, (ii) H2, PtO2; Multistep reaction;
参考文献
Anderson,F.E. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, # 2 p. 221 - 230
反应条件
2: 83percent m-chloroperbenzoic acid (MCPBA) / CHCl3 / 3 h / 10 - 15 °C
3: 70.8 percent / Ag2O / acetone
View Scheme
参考文献
Georgiadis, Minas P.; Couladouros, Elias A.; Polissiou, Moschos G.; Filippakis, S. E.; Mentzafos, D.; Terzis, A.
Journal of Organic Chemistry, 1982 , vol. 47, # 16 p. 3054 - 3058
反应条件
bromine in dichloromethane
3 h;
参考文献
ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan, A.; HOLLAND, Richard; ZHANG, Lingyun; PAJOUHESH, Hossein, O.; LAMONTAGNE, Jason; WHELAN, Brendan; SHORT, Glenn, F., III.; ROMERO, Donna, L.
Patent: WO2013/131018 A1, 2013 ;
Location in patent: Page/Page column 54; 55 ;
