5-(3-甲氧基苯基)戊酸合成路线 （共 24 条）
反应条件
1: polyphosphoric acid 2: LiAlH4 / diethyl ether 3: TsOH / benzene 4: NBS, (PhCO)2O2 / CCl4 / Irradiation 5: SeO2, aq. KH2PO4 / dioxane 6: Ag2O, aq. NaOH View Scheme
参考文献
Srivastava,K.C.; Dev,S.
Tetrahedron, 1972 , vol. 28, p. 1083 - 1091
反应条件
1: 99 percent / Br2 / CHCl3 / 2 h / Ambient temperature 2: 60 percent / polyphosphoric acid / 8 h / 55 °C 3: 96 percent / H2, triethylamine / 7percent Pd-C / ethanol / 3.5 h / Ambient temperature 4: 98 percent / pyridinium chloride / 1 h / 200 °C 5: 95 percent / pyridine / 5 h / Ambient temperature 6: 66 percent / Br2 / CCl4 / 3 h / Ambient temperature 7: 74 percent / LiCl / dimethylformamide / 3 h / Heating 8: K3PO4 / dimethylsulfoxide / 0.5 h / 60 °C 9: 97 percent / 2 M aq.KOH / ethanol 10: 60 percent / acetonitrile / 0.17 h / Ambient temperature; Irradiation View Scheme
参考文献
Horaguchi, Takaaki; Hasegawa, Eietsu; Shimizu, Takahachi; Tanemura, Kiyoshi; Suzuki, Tsuneo
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 365 - 369
反应条件
PPA in chlorobenzene T=80°C; 15 h;
参考文献
WO2012/50848 A1, ;
Page/Page column 115-116 ;
反应条件
1: polyphosphoric acid 2: LiAlH4 / diethyl ether 3: TsOH / benzene View Scheme
参考文献
Srivastava,K.C.; Dev,S.
Tetrahedron, 1972 , vol. 28, p. 1083 - 1091
反应条件
boron tribromide in dichloromethane
参考文献
Khalaf, Abedawn I.; Proctor, George R.; Suckling, Colin J.; Bence, Laura H.; Irvine, June I.; Stimson, William H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 12 p. 1475 - 1482
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
12 h;
参考文献
BAYLOR UNIVERSITY
Patent: US2012/130129 A1, 2012 ;
Location in patent: Page/Page column 16 ;
反应条件
1: With lithium hydroxide hydrate; water in tetrahydrofuran; methanol
T=-5 - 20°C; 15 h;
2: With hydrogenchloride in water
pH=2 - 3;
参考文献
SCHERING CORPORATION; COBURN, Craig, A.; LAVEY, Brian, J.; DWYER, Michael, P.; KOZLOWSKI, Joseph, A.; ROSENBLUM, Stuart, B.
Patent: WO2012/50848 A1, 2012 ;
Location in patent: Page/Page column 115 ;
反应条件
1: KOH / ethanol; H2O / 1 h / Heating
2: 88 percent / 0.67 h / 190 °C
View Scheme
参考文献
Horaguchi, Takaaki; Hasegawa, Eietsu; Shimizu, Takahachi; Tanemura, Kiyoshi; Suzuki, Tsuneo
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 365 - 369
反应条件
hydrogen; nickel in ethanol
参考文献
Khan,A.M. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 990 - 994
反应条件
1: With sodium hydroxide; water in ethanol
5 h; Heating / reflux;
2: With hydrogenchloride in water
参考文献
EMISPHERE TECHNOLOGIES, INC.
Patent: WO2008/112368 A2, 2008 ;
Location in patent: Page/Page column 28-29 ;
