1-乙基嘧啶-2,4(1H,3H)-二酮合成路线 （共 11 条）
反应条件
sodium methylate in methanol
T=20°C; 24 h;
参考文献
Paryzek, Zdzislaw; Tabaczka, Bartlomiej
Organic Preparations and Procedures International, 2001 , vol. 33, # 4 p. 400 - 405
反应条件
potassium hydroxide in ethanol
4 h; Heating;
参考文献
Robin, Aelig; Julienne, Karine; Meslin, Jean-Claude; Deniaud, David
European Journal of Organic Chemistry, 2006 , # 3 p. 634 - 643
反应条件
trimethylsilyl trifluoromethanesulfonate in 1,2-dichloro-ethane
T=20°C; 16 h;
参考文献
Mikhailov, Sergei N.; Padyukova, Nelly Sh.; Karpeiskii, Marat Ya.; Kolobushkina, Lidiya I.; Beigelman, Leon N.
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 4 p. 1055 - 1066
反应条件
1: 4-Methoxy pyrimidin-2-one With lithium hydride in N,N-dimethyl-formamide
T=60°C; 0.5 h;
2: diethyl sulphate in N,N-dimethyl-formamide
T=60°C; 48 h;
参考文献
Gambacorta, Augusto; Tofani, Daniela; Loreto, Maria Antonietta; Gasperi, Tecla; Bernini, Roberta
Tetrahedron, 2006 , vol. 62, # 29 p. 6848 - 6854
反应条件
1: [131I]-Uracil With lithium hydride in N,N-dimethyl-formamide
T=60°C; 0.5 h;
2: diethyl sulphate in N,N-dimethyl-formamide
T=60°C; 72 h;
参考文献
Gambacorta, Augusto; Tofani, Daniela; Loreto, Maria Antonietta; Gasperi, Tecla; Bernini, Roberta
Tetrahedron, 2006 , vol. 62, # 29 p. 6848 - 6854
反应条件
potassium carbonate in acetone
T=60 - 70°C; 24 h;
参考文献
Ishikawa; Itoh; Takayanagi; Oshima; Kawahara; Mizuno; Ogura
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 8 p. 1922 - 1930
反应条件
1: in water
T=4°C; Ring cleavage; addition; pH=11.3; 40 h; UV-irradiation;
2: With hydrogenchloride
cyclocondensation; 0.75 h; Heating;
参考文献
Hom, Kellie; Strahan, Gary; Shetlar, Martin D.
Photochemistry and Photobiology, 2000 , vol. 71, # 3 p. 243 - 253
参考文献
Hilbert
Journal of the American Chemical Society, 1937 , vol. 59, p. 330,333
反应条件
1: in water
T=4°C; Ring cleavage; addition; pH=10.5; 15 h; UV-irradiation;
2: With hydrogenchloride
cyclocondensation; 0.75 h; Heating;
参考文献
Hom, Kellie; Strahan, Gary; Shetlar, Martin D.
Photochemistry and Photobiology, 2000 , vol. 71, # 3 p. 243 - 253
反应条件
sodium hydride
1.) dioxane, 50 deg C, 2.) reflux; Yield given. Multistep reaction;
参考文献
Winckelmann, Ib; Larsen, Erik H.
Synthesis, 1986 , # 12 p. 1041 - 1044
