2-溴-4,5-二氟苯甲酸合成路线 （共 17 条）
反应条件
aluminium trichloride in water
参考文献
PFIZER INC.
Patent: EP342849 A3, 1990 ;
反应条件
hydrogenchloride in sodium hypobromide
反应条件
1: KF / tetrahydrothiophene 1,1-dioxide / 2 h / 185 °C 2: 2.) oxalyl chloride / 1.) 10 min, 2.) CH2Cl2, 16 h 3: 75 percent / tetrahydrofuran / 24 h 4: CCl3Br, AIBN / 6 h / Heating 5: aq. LiOH / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 22, # 21 p. 3067 - 3074
反应条件
1: 2.) oxalyl chloride / 1.) 10 min, 2.) CH2Cl2, 16 h 2: 75 percent / tetrahydrofuran / 24 h 3: CCl3Br, AIBN / 6 h / Heating 4: aq. LiOH / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 22, # 21 p. 3067 - 3074
反应条件
sulfuric acid in acetic acid Heating;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 6 p. 2001 - 2017
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile a) 0 deg C, 2 h, b) RT, overnight;
参考文献
Synthetic Communications, , vol. 22, # 21 p. 3067 - 3074
反应条件
lithium hydroxide in tetrahydrofuran 3 h; Ambient temperature; Yield given;
参考文献
Synthetic Communications, , vol. 22, # 21 p. 3067 - 3074
反应条件
1: 75 percent / tetrahydrofuran / 24 h 2: CCl3Br, AIBN / 6 h / Heating 3: aq. LiOH / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 22, # 21 p. 3067 - 3074
反应条件
1: CCl3Br, AIBN / 6 h / Heating 2: aq. LiOH / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 22, # 21 p. 3067 - 3074
反应条件
1: Br2, Fe / Heating 2: (nitration) 3: Fe, aq. NH4Cl / Heating 4: (i) aq. NaNO2, H2SO4, (ii) /BRN= 4652394/, CuSO4, aq. NH3, CHCl3 5: aq. H2SO4 / acetic acid / Heating View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 6 p. 2001 - 2017
