potassium hydroxide in tetrahydrofuran; methanol T=20°C; 2 h;

1: AcOH; H3PO4; aq. HCl / dioxane / 24 h / 80 °C 2: 0.56 g / K2CO3 / 48 h / 80 °C 3: 48 percent / Cs2CO3 / acetone / 24 h / Heating 4: 100 percent / aq. KOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1: 0.56 g / K2CO3 / 48 h / 80 °C 2: 48 percent / Cs2CO3 / acetone / 24 h / Heating 3: 100 percent / aq. KOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

1: 48 percent / Cs2CO3 / acetone / 24 h / Heating 2: 100 percent / aq. KOH / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme

thionyl chloride in benzene 2 h; Heating;