2-溴-4-甲氧基-5-苄氧基苯甲醛合成路线 （共 22 条）
反应条件
1: hydrogenchloride / water / 10 h / 90 °C 2: ethanol / 18 h / |Reflux View Scheme
参考文献
Journal of the American Chemical Society, , vol. 136, # 6 p. 2583 - 2591
反应条件
1: 49.1 percent / CH3ONa, C6H5CH2OH, DMSO / 0.33 h / 150 °C 2: 87.9 percent / K2CO3 / 6 h / 100 °C View Scheme
参考文献
Heterocycles, , vol. 31, # 6 p. 1067 - 1076
反应条件
1: 9.3 percent / C6H5ONa, DMSO / 0.33 h / 170 °C 2: 82.6 percent / 2percent NaOH / 1 h / 85 °C View Scheme
参考文献
Heterocycles, , vol. 31, # 6 p. 1067 - 1076
反应条件
1: 15.5 percent / CH3ONa, CH3OH, DMSO / 0.33 h / 170 °C 2: 87.9 percent / K2CO3 / 6 h / 100 °C View Scheme
参考文献
Heterocycles, , vol. 31, # 6 p. 1067 - 1076
参考文献
WO2006/72818 A2, ;
Page/Page column 18 ;
反应条件
chloro-trimethyl-silane; sodium iodide in dichloromethane debenzylation;
参考文献
Ohmori, Osamu; Takayama, Hiromitsu; Kitajima, Mariko; Aimi, Norio
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 10 p. 1512 - 1513
反应条件
potassium permanganate in methanol; water T=50 - 55°C;
参考文献
Reddy, Jambula Mukunda; Kumar, Kotagiri Vijay; Raju, Veeramalla; Bhaskar, Bolguddu Vijay; Himabindu, Vurumidi; Bhattacharya, Apurba; Sundaram, Venkatram; Banerjee, Rahul; Reddy, Ghanta Mahesh; Bandichhor, Rakeshwar
Synthetic Communications, 2008 , vol. 38, # 13 p. 2138 - 2149
反应条件
1: 71 percent / NaOMe / methanol / 4 °C
2: xylene / Heating
3: LiAlH4 / diethyl ether / Heating
4: 84 percent / MnO2 / CH2Cl2 / Heating
5: 70 percent / (Ph3P)2Rh(CO)Cl, 1,3-bis(diphenylphosphino)propane / 1,3,5-trimethyl-benzene / Heating
6: 57 percent / 1.) t-BuLi / 1.) THF, -78 deg C, 2.) -78 deg C to room temp.
View Scheme
参考文献
Bolton, Richard E.; Moody, Christopher, J.; Rees, Charles W.; Tojo, Gabriel
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 931 - 936
反应条件
1: 85 percent / ammonium acetate; acetic acid / 4 h / 100 °C
2: 80 percent / sodium borohydride / ethanol / 2 h / 0 °C
View Scheme
参考文献
Chandrasekhar; Reddy, N. Ramakrishna; Rao, Y. Srinivasa
Tetrahedron, 2006 , vol. 62, # 51 p. 12098 - 12107
反应条件
1.1: 88 percent / Na2CO3; LiCl / [Pd(PPh3)4] / 1,2-dimethoxy-ethane; H2O / 80 °C
2.1: LDA / tetrahydrofuran; hexane / -78 °C
2.2: 79 percent / tetrahydrofuran; hexane / -78 - 20 °C
3.1: 73 percent / PtCl2 / toluene / 80 °C
4.1: 79 percent / H2 / Pd/C / ethyl acetate / 760 Torr
View Scheme
参考文献
Mamane, Victor; Hannen, Peter; Fuerstner, Alois
Chemistry - A European Journal, 2004 , vol. 10, # 18 p. 4556 - 4575
