6,11-二氢-5H-苯并[b]咔唑-6,11-二酮合成路线 （共 22 条）
反应条件
sodium tetrahydroborate in isopropyl alcohol
T=20°C; 2 h;
参考文献
Cruces, Jacobo; Estevez, Juan C; Castedo, Luis; Estevez, Ramon J
Tetrahedron Letters, 2001 , vol. 42, # 29 p. 4825 - 4827
反应条件
copper diacetate; palladium diacetate in N,N-dimethyl-formamide
T=130°C; 1 h; Sealed tubeMicrowave irradiation;
参考文献
Sridharan, Vellaisamy; Antonia Martin; Carlos Menendez
European Journal of Organic Chemistry, 2009 , # 27 p. 4614 - 4621
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
T=-78 - 0°C; 3 h;
参考文献
Fernandez, Marcos; Barcia, Carlos; Estevez, Juan C.; Estevez, Ramon J.; Castedo, Luis
Synlett, 2004 , # 2 p. 267 - 270
反应条件
1: With boron tribromide in hexane; dichloromethane
T=20°C; 1 h;
2: With ammonium chloride in hexane; dichloromethane
T=60°C; 1 h;
参考文献
Bernardo, Paul H.; Chai, Christina L. L.; Heath, Graham A.; Mahon, Peter J.; Smith, Geoffrey D.; Waring, Paul; Wilkes, Bronwyn A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4958 - 4963
反应条件
4-methylmorpholine N-oxide; tetra-n-butylammonium per-ruthenate in dichloromethane
5 h; Ambient temperature;
参考文献
Griffith, William P.; Ley, Steven V.; Whitcombe, Gwynne P.; White, Andrew D.
Journal of the Chemical Society, Chemical Communications, 1987 , p. 1625 - 1627
参考文献
Mal, Dipakranjan; Senapati, Bidyut Kumar; Pahari, Pallab
Tetrahedron, 2007 , vol. 63, # 18 p. 3768 - 3781
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
T=-78 - 20°C;
参考文献
Ketcha, Daniel M.; Gribble, Gordon W.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5451 - 5457
反应条件
1: 59 percent / K2CO3 / dimethylsulfoxide / 72 h / 100 °C
2: H2 / PtO2 / ethyl acetate / 0.5 h / 760 Torr / Ambient temperature
3: air / ethyl acetate / 24 h / Heating
View Scheme
参考文献
Kobayashi, Kazuhiro; Taki, Tetsuya; Kawakita, Masataka; Uchida, Masaharu; Morikawa, Osamu; Konishi, Hisatoshi
Heterocycles, 1999 , vol. 51, # 2 p. 349 - 354
反应条件
1.1: ZnCl2; MeMgCl / CH2Cl2 / 1 h / 20 °C
1.2: 76 percent / CH2Cl2 / 20 °C
2.1: NaH / tetrahydrofuran / 0.33 h / 0 °C
2.2: 93 percent / tetrahydrofuran / 16 h / 20 °C
3.1: 88 percent / TMEDA; LHMDS / tetrahydrofuran / -78 - 20 °C
4.1: BBr3 / CH2Cl2; hexane / 1 h / 20 °C
4.2: 57 percent / aq. NH4Cl / CH2Cl2; hexane / 1 h / 60 °C
View Scheme
参考文献
Bernardo, Paul H.; Chai, Christina L. L.; Heath, Graham A.; Mahon, Peter J.; Smith, Geoffrey D.; Waring, Paul; Wilkes, Bronwyn A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4958 - 4963
反应条件
1.1: NaH / tetrahydrofuran / 0.33 h / 0 °C
1.2: 93 percent / tetrahydrofuran / 16 h / 20 °C
2.1: 88 percent / TMEDA; LHMDS / tetrahydrofuran / -78 - 20 °C
3.1: BBr3 / CH2Cl2; hexane / 1 h / 20 °C
3.2: 57 percent / aq. NH4Cl / CH2Cl2; hexane / 1 h / 60 °C
View Scheme
参考文献
Bernardo, Paul H.; Chai, Christina L. L.; Heath, Graham A.; Mahon, Peter J.; Smith, Geoffrey D.; Waring, Paul; Wilkes, Bronwyn A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4958 - 4963
