1-(2-氯苯基)-1,2-丙二酮合成路线 （共 6 条）
反应条件
hydrogenchloride; formaldehyd; water in ethanol
T=80°C; 0.3 h; Microwave irradiation;
参考文献
Liu, Yu; Yun, Xiliu; Zhang-Negrerie, Daisy; Huang, Jianhui; Du, Yunfei; Zhao, Kang
Synthesis, 2011 , # 18 art. no. H55411SS, p. 2984 - 2994
反应条件
pyridine; pyridinium chlorochromate in dichloromethane
24.5 - 26.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
AMGEN INC.
Patent: WO2008/118468 A1, 2008 ;
Location in patent: Page/Page column 65; 132-133 ;
反应条件
2,2'-azo-bisisobutyronitrile; oxygen; palladium diacetate; sodium carbonate
T=120°C; P=6080.41 Torr; 20 h; Autoclave;
参考文献
Wang, Azhong; Jiang, Huanfeng; Li, Xianwei
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6958 - 6961
反应条件
bismuth(III)oxide; acetic acid in 2-ethoxy-ethanol
T=105°C; 2 h;
参考文献
Stetter,H.; Daembkes,G.
Synthesis, 1977 , p. 403 - 404
反应条件
1: 5-(2-hydroxy-ethyl)-3,4-dimethyl-thiazolium iodide, Et3N / ethanol / 16 h / Heating
2: Bi2O3, AcOH / 2-ethoxy-ethanol / 2 h / 105 °C
View Scheme
参考文献
Stetter,H.; Daembkes,G.
Synthesis, 1977 , p. 403 - 404
反应条件
1: sodium acetate / ethanol; water / 2 h
2: oxygen; sodium hydride / N,N-dimethyl-formamide / 0.3 h / 20 °C
3: hydrogenchloride; formaldehyd; water / ethanol / 0.3 h / 80 °C / Microwave irradiation
View Scheme
参考文献
Liu, Yu; Yun, Xiliu; Zhang-Negrerie, Daisy; Huang, Jianhui; Du, Yunfei; Zhao, Kang
Synthesis, 2011 , # 18 art. no. H55411SS, p. 2984 - 2994
