[6R-[6alpha,7beta(Z)]]-3-(乙酰氧基甲基)-7-[[2-(氯乙酰氨基)噻唑-4-基](甲氧基亚胺)乙酰氨基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸合成路线 （共 2 条）
反应条件
1: 65 percent / aq. NaHCO3; CaCl2*2H2O / 1.25 h / 70 °C 2: 2.4 g / dicyclohexylamine / N,N-dimethyl-acetamide / 0.75 h / 0 - 5 °C 3: 1.44 g / thiourea / N,N-dimethyl-acetamide / 3 h / 20 °C View Scheme
参考文献
Rodriguez, Juan C.; Hernandez, Ricardo; Gonzalez, Maritza; Rodriguez, Zalua; Tolon, Blanca; Velez, Herman; Valdes, Barbara; Lopez, Miguel A.; Fini, Adamo
Farmaco, 2003 , vol. 58, # 5 p. 363 - 369
反应条件
1: With water; sodium carbonate; thiourea; isopropyl alcohol T=20 - 30°C; 2: With hydrogenchloride; water in isopropyl alcohol T=20 - 30°C; pH=2.7 - 3.0; 2 h;
参考文献
Wockhardt Limited
Patent: US2007/4916 A1, 2007 ;
Location in patent: Page/Page column 4 ;
