1: With boron tribromide in dichloromethane T=0 - 20°C; 2: With methanol in dichloromethane 3: With sodium hydrogencarbonate in water Saturated solution;
参考文献
AMBIT BIOSCIENCES CORPORATON
Patent: WO2009/117080 A1, 2009 ;
Location in patent: Page/Page column 171 ;
WO 2009/117080 A1
1: With hydrogenchloride; acetic acid; sodium nitrite in water
T=0°C; 0.166667 h;
2: With sulfur dioxide; acetic acid; copper dichloride in water
T=0 - 20°C;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/123731 A2, 2005 ;
Location in patent: Page/Page column 68-69 ;
WO 2005/123731 A2
