2-(3-硝基吡啶-2-基)丙二酸二乙酯合成路线 （共 17 条）
反应条件
1: aq. LiCl / dimethylsulfoxide 2: H2 / Pd/C / ethanol / 2068.59 Torr 3: HCl / diethyl ether View Scheme
参考文献
Wood, Edgar R.; Kuyper, Lee; Petrov, Kimberly G.; Hunter III, Robert N.; Harris, Philip A.; Lackey, Karen
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 4 p. 953 - 957
反应条件
1: aq. LiCl / dimethylsulfoxide 2: H2 / Pd/C / ethanol / 2068.59 Torr View Scheme
参考文献
Wood, Edgar R.; Kuyper, Lee; Petrov, Kimberly G.; Hunter III, Robert N.; Harris, Philip A.; Lackey, Karen
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 4 p. 953 - 957
反应条件
1: 86 percent / aq. HCl / 8 h / Heating 2: dimethylformamide / 4.25 h / 90 °C 3: 0.31 g / HCOOH / Pd/C / methanol / 4 h View Scheme
参考文献
Cash, Michael T.; Schreiner, Peter R.; Phillips, Robert S.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 20 p. 3701 - 3706
反应条件
lithium chloride in water; dimethyl sulfoxide
参考文献
SmithKline Beecham Corporation
Patent: US6624171 B1, 2003 ;
US 6624171 B1
反应条件
in xylene 24 h; Heating;
参考文献
Duffy, Kevin J.; Tennant, George
Journal of the Chemical Society, Chemical Communications, 1995 , # 23 p. 2457 - 2460
反应条件
hydrogenchloride 8 h; Heating;
参考文献
Cash, Michael T.; Schreiner, Peter R.; Phillips, Robert S.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 20 p. 3701 - 3706
反应条件
1.1: sulfuric acid; water / 50 - 100 °C / Large scale reaction 2.1: sodium ethanolate / tetrahydrofuran / 10 - 20 °C / Large scale reaction 2.2: 2 h / 20 °C 3.1: palladium 10 on activated carbon; ammonium formate; acetic acid / ethanol; water / 3.25 h / 35 °C / Large scale reaction View Scheme
参考文献
Wang, Jia; Wang, Xiang; Chen, Yanhong; Chen, Simeng; Chen, Guang; Tong, Linjiang; Meng, Linghua; Xie, Yuyuan; Ding, Jian; Yang, Chunhao
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 339 - 342
反应条件
1.1: sulfuric acid; water / 50 - 100 °C / Large scale reaction 2.1: sodium ethanolate / tetrahydrofuran / 10 - 20 °C / Large scale reaction 2.2: 2 h / 20 °C 3.1: palladium 10 on activated carbon; ammonium formate; acetic acid / ethanol; water / 3.25 h / 35 °C / Large scale reaction 4.1: ammonia / 36 h / 50 °C View Scheme
参考文献
Huang, Bao-Guo; Kubiak, Gregory; Shay, John J.; Pemberton, Clive; Peers, James; Hanna, Reda G.; Powers, Matthew R.; Gamboa, Juan A.; Gelormini, Ann M.; Yarabe, Hyacinthe; Rudisill, Duane E.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1040 - 1045
反应条件
1.1: sulfuric acid; water / 50 - 100 °C / Large scale reaction 2.1: sodium ethanolate / tetrahydrofuran / 10 - 20 °C / Large scale reaction 2.2: 2 h / 20 °C 3.1: palladium 10 on activated carbon; ammonium formate; acetic acid / ethanol; water / 3.25 h / 35 °C / Large scale reaction 4.1: ammonia; water / 5 h / 60 °C / 1034.32 Torr View Scheme
参考文献
Huang, Bao-Guo; Kubiak, Gregory; Shay, John J.; Pemberton, Clive; Peers, James; Hanna, Reda G.; Powers, Matthew R.; Gamboa, Juan A.; Gelormini, Ann M.; Yarabe, Hyacinthe; Rudisill, Duane E.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1040 - 1045
反应条件
in dimethyl sulfoxide
参考文献
SmithKline Beecham Corporation
Patent: US6624171 B1, 2003 ;
US 6624171 B1
