3,4,5-三甲氧基苯酚合成路线 （共 94 条）
反应条件
1: 67 percent / trimethylsilyl trifluoromethanesulfonate / CH2Cl2; toluene / -30 - 20 °C 2: 82 percent / lutidine; DMAP / CH2Cl2 / 0 - 20 °C 3: 68 percent / potassium acetate; dppf; dppp / palladium acetate / dimethylsulfoxide / 15 h / 75 °C 4: 100 percent / H2; palladium hydroxide on activated carbon / methanol; acetic acid; H2O / 10 h 5: 90 percent / SOCl2 / methanol / 0 °C View Scheme
参考文献
Herzner, Holger; Palmacci, Emma R.; Seeberger, Peter H.
Organic Letters, 2002 , vol. 4, # 17 p. 2965 - 2967
反应条件
sodium acetate T=110°C; 2 h;
参考文献
Yoon, Hyunjun; Kim, Mi Kyoung; Mok, Hyejung; Chong, Youhoon
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 8 p. 2803 - 2805
反应条件
potassium phosphate in toluene T=0 - 20°C;
参考文献
Mori, Akinori; Mizusaki, Tomoteru; Ikawa, Takashi; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao
Tetrahedron, 2007 , vol. 63, # 5 p. 1270 - 1280
反应条件
P2O5; methanesulfonic acid 4 h; Ambient temperature;
参考文献
McGarry, Lynda W.; Detty, Michael R.
Journal of Organic Chemistry, 1990 , vol. 55, # 14 p. 4349 - 4356
反应条件
1: 85 percent / NaH / dimethylformamide / 20 °C 2: 60 percent / polyphosphoric acid / 8 h / 80 °C 3: 31 percent / Al2O3 / CH2Cl2 / 20 °C 4: 20 percent / KCN / ethanol; CH2Cl2 / 12 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 21 p. 3759 - 3763
反应条件
1: 96 percent / AcONa / 3 h / 110 °C 2: 94 percent / BF3*Et2O / 2 h / 70 °C 3: 89 percent / KOH / ethanol / 0 - 20 °C 4: 74 percent / iodine / dimethylsulfoxide / 2 h / 190 - 200 °C View Scheme
参考文献
Molecules, , vol. 12, # 1 p. 86 - 97
反应条件
P2O5; methanesulfonic acid 12 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 55, # 14 p. 4349 - 4356
反应条件
1: boron trifluoride diethyl etherate / 2 h / 75 °C 2: potassium hydroxide / methanol / 50 h / 20 °C 3: iodine / dimethyl sulfoxide / 4 h / 110 °C 4: pyridine hydrochloride / 8 h / 190 °C / |Inert atmosphere 5: 4 h / |Heating View Scheme
参考文献
Chen, Duo-Zhi; Wu, Ting; Zhao, Zhao; Lin, Xi-Quan; Yang, Tao; Yang, Jian
Journal of Chemical Research, 2013 , vol. 37, # 11 p. 671 - 673
反应条件
1.1: 72 percent / BF3*OEt2 / 0.25 h / Heating
2.1: formic acid / tetrahydrofuran / 1 h / 0 °C
2.2: 72 percent / tetrahydrofuran / 12.5 h / 0 - 100 °C
3.1: 79 percent / BBr3 / CH2Cl2 / 13 h / -80 - 20 °C
View Scheme
参考文献
Gao, Hong; Kawabata, Jun
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1661 - 1671
反应条件
aluminium trichloride; nitrobenzene
参考文献
Chapman; Perkin; Robinson
Journal of the Chemical Society, 1927 , p. 3020
