2-(2-甲基-1,3-二氧杂环戊烷-2-基)乙酸乙酯合成路线 （共 15 条）
反应条件
1: 91 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C
2: 75 percent / oxalyl chloride; DMSO; triethylamine / tetrahydrofuran; CH2Cl2 / -78 - 0 °C
3: 88 percent / tetrahydrofuran / 0 - 20 °C
4: 89 percent / diisopropylamine / CH2Cl2 / 17 h / 20 °C
View Scheme
参考文献
Nogawa, Masaki; Sugawara, Satomi; Iizuka, Rie; Shimojo, Megumi; Ohta, Hiromichi; Hatanaka, Minoru; Matsumoto, Kazutsugu
Tetrahedron, 2006 , vol. 62, # 51 p. 12071 - 12083
反应条件
1: LiAlH4
2: 1.) tosylation; 2.) NaI
View Scheme
参考文献
Keinan, Ehud; Sinha, Subhash C.; Sinha-Bagchi, Anjana
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 12 p. 3333 - 3340
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0°C;
参考文献
Duhamel, Lucette; Ancel, Jean-Erick
Tetrahedron, 1992 , vol. 48, # 42 p. 9237 - 9250
参考文献
Rhone-Poulenc Sante
Patent: US4876370 A1, 1989 ;
反应条件
1: 81 percent / LiAlH4
2: 76 percent / (COCl)2, Et3N / dimethylsulfoxide
3: 49 percent / BF3*OEt2
View Scheme
参考文献
Uchino, Keiso; Yamagiwa, Yoshiro; Kamikawa, Tadao; Kubo, Isao
Tetrahedron Letters, 1985 , vol. 26, # 10 p. 1319 - 1320
