N-Boc-L-正亮氨酸合成路线 （共 27 条）
反应条件
Yield given. Multistep reaction;
参考文献
Fournier; Couture; Regoli; Gendreau; St-Pierre
Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 64 - 68
反应条件
sodium hydride in tetrahydrofuran 24 h; Ambient temperature;
参考文献
Kajiyama, Shin-Ichiro; Irie, Kazuhiro; Kido, Takae; Koshimizu, Koichi; Hayashi, Hideo; Arai, Motoo
Tetrahedron, 1991 , vol. 47, # 29 p. 5453 - 5462
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran T=-5 - 20°C; 3 h;
参考文献
Furutani, Masahiro; Kudo, Kazuaki
Chemistry Letters, 2013 , vol. 42, # 6 p. 601 - 603
反应条件
1: 100 percent / DCC / CH2Cl2 / 18 h 2: 1.) aq. HCl, 2.) aq. NaHCO3 / 1.) CHCl3 3: LiAlH4 / tetrahydrofuran / 15 h / Heating View Scheme
参考文献
Williams; Ciccarone; MacTough; Bock; Conner; Davide; Hamilton; Koblan; Kohl; Kral; Mosser; Omer; Pompliano; Rands; Schaber; Shah; Wilson; Gibbs; Graham; et al.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1345 - 1348
反应条件
1: With 4-methyl-morpholine; chloroformic acid ethyl ester in tetrahydrofuran T=-10°C; 0.333333 h; 2: With sodium tetrahydroborate in tetrahydrofuran; methanol T=0°C; 0.666667 h;
参考文献
Shinozuka, Tsuyoshi; Shimada, Kousei; Matsui, Satoshi; Yamane, Takahiro; Ama, Mayumi; Fukuda, Takeshi; Taki, Motohiko; Takeda, Yuko; Otsuka, Eri; Yamato, Michiko; Mochizuki, Shin-ichi; Ohhata, Keiko; Naito, Satoru
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 20 p. 6789 - 6806
反应条件
1: 100 percent / DCC / CH2Cl2 / 18 h 2: 1.) aq. HCl, 2.) aq. NaHCO3 / 1.) CHCl3 3: LiAlH4 / tetrahydrofuran / 15 h / Heating 4: CH2Cl2 / 2 h 5: 100 percent / H2 / 10percent Pd/C / methanol / 16 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 7 p. 1345 - 1348
反应条件
1: With 4-methyl-morpholine; chloroformic acid ethyl ester in tetrahydrofuran T=-10°C; 0.333333 h; 2: With sodium tetrahydroborate in tetrahydrofuran; methanol T=0°C; 0.666667 h;
参考文献
Shinozuka, Tsuyoshi; Shimada, Kousei; Matsui, Satoshi; Yamane, Takahiro; Ama, Mayumi; Fukuda, Takeshi; Taki, Motohiko; Takeda, Yuko; Otsuka, Eri; Yamato, Michiko; Mochizuki, Shin-ichi; Ohhata, Keiko; Naito, Satoru
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 20 p. 6789 - 6806
