1-苯乙基-4-苯基-4-哌啶基乙酸酯合成路线 （共 13 条）
反应条件
1: Cl2
2: 180 °C
View Scheme
参考文献
Drach,B.S.; Kovalev,V.A.
Journal of Organic Chemistry USSR (English Translation), 1977 , vol. 13, p. 1474 - 1480
Zhurnal Organicheskoi Khimii, 1977 , vol. 13, p. 1597 - 1603
反应条件
1: PCl5 / benzene
2: tetrahydrofuran; methanol
View Scheme
参考文献
Drach,B.S.; Kovalev,V.A.
Journal of Organic Chemistry USSR (English Translation), 1977 , vol. 13, p. 1474 - 1480
Zhurnal Organicheskoi Khimii, 1977 , vol. 13, p. 1597 - 1603
反应条件
in tetrahydrofuran; methanol
参考文献
Drach,B.S.; Kovalev,V.A.
Journal of Organic Chemistry USSR (English Translation), 1977 , vol. 13, p. 1474 - 1480
Zhurnal Organicheskoi Khimii, 1977 , vol. 13, p. 1597 - 1603
反应条件
hydrogenchloride in 1,4-dioxane
参考文献
Drach,B.S.; Kovalev,V.A.
Journal of Organic Chemistry USSR (English Translation), 1977 , vol. 13, p. 1474 - 1480
Zhurnal Organicheskoi Khimii, 1977 , vol. 13, p. 1597 - 1603
反应条件
1: aq. HCl / dioxane
2: PCl5
View Scheme
参考文献
Drach,B.S.; Kovalev,V.A.
Journal of Organic Chemistry USSR (English Translation), 1977 , vol. 13, p. 1474 - 1480
Zhurnal Organicheskoi Khimii, 1977 , vol. 13, p. 1597 - 1603
参考文献
Drach,B.S.; Kovalev,V.A.
Journal of Organic Chemistry USSR (English Translation), 1977 , vol. 13, p. 1474 - 1480
Zhurnal Organicheskoi Khimii, 1977 , vol. 13, p. 1597 - 1603
反应条件
1: 1) triethylamine, 2) Cl2 / 1) THF, 20-25 deg C, 8-10 d; 2) CH2Cl2, CCl4, 20-25 deg C, 2 h
2: 30 percent / NaOH / aq. ethanol / 0.05 h / Heating
View Scheme
参考文献
Popovich, T.P.; Drach, B.S.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 11 p. 2158 - 2164
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 11 p. 2443 - 2450
参考文献
Sakamoto, Masami; Aoyama, Hiromu; Omote, Yoshimori
Journal of Organic Chemistry, 1984 , vol. 49, # 10 p. 1837 - 1838
反应条件
1: tetrahydrofuran / Ambient temperature
2: 44 percent Chromat. / NaBH4 / methanol / 2 h
View Scheme
参考文献
Sundberg, Richard J.; Walters, Claudia Powers; Bloom, Jonathan D.
Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3730 - 3732
反应条件
1: (1S)-(+)-N-(2,2-dimethylpropionyl)-1-phenylethylamine With n-butyllithium; tert.-butyl lithium in tetrahydrofuran; hexane; pentane T=-78 - -60°C; 2: carbonic acid diethyl ester in tetrahydrofuran; hexane; pentane T=-78 - 20°C; Further stages.;
参考文献
McAlonan; Murphy; Nieuwenhuyzen; Reynolds; Sarma; Stevenso; Thompson
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 1 p. 69 - 79
