反应条件
1: (i) CuI, ether, THF, (ii) /BRN= 1759822/
2: iBu2AlH / pentane; hexane
3: LiBr, PBr3, collidine / diethyl ether
4: (i) EtMgBr, ether, THF, (ii) /BRN= 1902461/, CuCl
5: H2, quinoline / Lindlar catalyst / pentane / 4 h / 15 °C
View Scheme
参考文献
Dawson,M.I. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 1396 - 1400
