4-氨基-3-硝基苯甲腈合成路线 （共 32 条）
反应条件
1: 68 percent / NH2OH*HCl; NaOH / ethanol; H2O / 7 h / 20 °C 2: NaOH; diethyl chlorophosphate / dimethylsulfoxide-d6; D2O View Scheme
参考文献
New Journal of Chemistry, , vol. 29, # 11 p. 1469 - 1474
反应条件
1: 52 percent / HNO3; water / 2 h 2: 75 percent / HCl / 2 h / 75 °C 3: 68 percent / NH2OH*HCl; NaOH / ethanol; H2O / 7 h / 20 °C 4: NaOH; diethyl chlorophosphate / dimethylsulfoxide-d6; D2O View Scheme
参考文献
New Journal of Chemistry, , vol. 29, # 11 p. 1469 - 1474
反应条件
ammonium hydroxide; ethanol
参考文献
Helvetica Chimica Acta, , vol. 26, p. 1125,1127
反应条件
1: thionyl chloride 2: ethanol; aqueous ammonia View Scheme
参考文献
Helvetica Chimica Acta, , vol. 26, p. 1125,1127
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol / 0.5 h / 20 °C / 1137.76 - 2172.08 Torr 2: Na2S2O5 / ethanol; water / 5 h / Reflux 3: nickel-aluminum alloy; formic acid / water / 5 h / 95 °C / Inert atmosphere 4: Na2S2O5 / ethanol; water / 6 h / Reflux View Scheme
参考文献
Singh, Manish; Tandon, Vibha
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669
反应条件
1: 94.5 percent / H2 / 10percent Pd/C / ethyl acetate / 1.5 h / 2327.2 Torr 2: 54 percent / nitrobenzene / 145 °C 3: 60 percent / aq. formic acid / Ni-Al / 6 h / 95 °C 4: 31 percent / nitrobenzene / 145 °C View Scheme
参考文献
Jung Sun Kim; Gatto; Yu; Liu; LaVoie
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 992 - 998
反应条件
1: 94.5 percent / H2 / 10percent Pd/C / ethyl acetate / 1.5 h / 2327.2 Torr 2: 69 percent / nitrobenzene / 145 °C 3: 51 percent / aq. formic acid / Ni-Al / 6 h / 95 °C 4: 86 percent / nitrobenzene / 145 °C View Scheme
参考文献
Jung Sun Kim; Gatto; Yu; Liu; LaVoie
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 992 - 998
反应条件
1: 94.5 percent / H2 / 10percent Pd/C / ethyl acetate / 1.5 h / 2327.2 Torr 2: 60 percent / nitrobenzene / 145 °C 3: 60 percent / aq. formic acid / Ni-Al / 6 h / 95 °C 4: 18 percent / nitrobenzene / 145 °C View Scheme
参考文献
Jung Sun Kim; Gatto; Yu; Liu; LaVoie
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 992 - 998
反应条件
1: pyridine / CH2Cl2 / 0.5 h / -20 °C 2: HCl gas, molecular sieves 4A / diethyl ether / -20 °C 3: 1.171 g / AcOH / 12 h / 55 °C 4: H2 / 10percent Pd/C / methanol / 1.25 h / Ambient temperature 5: 80 percent / mol. sieves / nitrobenzene; toluene / 36 h / 98 - 100 °C View Scheme
参考文献
Harapanhalli; McLaughlin; Howell; Rao; Adelstein; Kassis
Journal of medicinal chemistry, 1996 , vol. 39, # 24 p. 4804 - 4809
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in water; toluene T=20°C; Methylation;
参考文献
Voskresensky; Makosza
Synthetic Communications, 2000 , vol. 30, # 19 p. 3523 - 3526
