4-氨基-3-硝基苯甲腈合成路线 （共 32 条）
反应条件
sulfuric acid; water 0.5 h; Heating / reflux;
参考文献
UNIVERSITY OF DELHI; TANDON, Vibha
Patent: WO2004/63170 A1, 2004 ;
Location in patent: Page 8 ;
反应条件
sulfuric acid; potassium nitrate Erwaermen des Reaktionsprodukts mit wss. H2SO4;
参考文献
Journal of the Chemical Society, , p. 1722,1725
反应条件
ammonia in methanol 72 h; Ambient temperature;
参考文献
Jung; Delvare; Boucherot; Hamon; Ackerley; Betts
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1110 - 1116
反应条件
2,4,6-trichlorosulfenamide; potassium tert-butylate in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Journal of Organic Chemistry, , vol. 63, # 15 p. 4878 - 4888
反应条件
iron(II) sulfate in dimethyl sulfoxide T=20°C; 1 h;
参考文献
Farmaco, , vol. 56, # 10 p. 799 - 802
反应条件
1: acetic acid / 0.25 h / Heating 2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min 3: conc. sulfuric acid / 0.25 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1786 - 1792
反应条件
1: 68 percent / fuming HNO3, conc. H2SO4 / 2 h / 10 - 15 °C 2: 63 percent / NH3 / methanol / 72 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 3 p. 1110 - 1116
反应条件
ammonia T=100°C; im Rohr;
参考文献
Chemische Berichte, , vol. 49, p. 2230
反应条件
sodium hydroxide; diethyl chlorophosphate in dimethylsulfoxide-d6; water-d2
参考文献
New Journal of Chemistry, , vol. 29, # 11 p. 1469 - 1474
反应条件
1: 75 percent / HCl / 2 h / 75 °C 2: 68 percent / NH2OH*HCl; NaOH / ethanol; H2O / 7 h / 20 °C 3: NaOH; diethyl chlorophosphate / dimethylsulfoxide-d6; D2O View Scheme
参考文献
New Journal of Chemistry, , vol. 29, # 11 p. 1469 - 1474
