1-苄基-4-苯基哌啶-4-醇合成路线 （共 30 条）
反应条件
1: 91 percent / P2O5 / toluene / Heating 2: 100 percent / H2 / Pd/C / ethanol View Scheme
参考文献
Sakamuri, Sukumar; Enyedy, Istvan J; Kozikowski, Alan P; Zaman, Wahiduz A; Johnson, Kenneth M; Wang, Shaomeng
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 495 - 500
反应条件
1: methanesulfonic acid / toluene / 4 h / Reflux 2: hydrogenchloride / diethyl ether; ethyl acetate 3: palladium 10 on activated carbon; hydrogen / ethanol / 44 h View Scheme
参考文献
Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
反应条件
1: AlCl3 / 1 h / 50 - 55 °C 2: 80 percent / H2 / 5percent Pd/BaSO4 / 7 h / 80 °C / 3750.3 Torr View Scheme
参考文献
Schaefer; Hackmack; Eistetter; Krueger; Menge; Klosa
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 3 p. 233 - 240
反应条件
sulfuric acid T=0 - 20°C; Ritter reaction;
参考文献
Tagad, Harichandra D.; Hamada, Yoshio; Nguyen, Jeffrey-Tri; Hidaka, Koushi; Hamada, Takashi; Sohma, Youhei; Kimura, Tooru; Kiso, Yoshiaki
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5238 - 5246
反应条件
sulfuric acid in acetonitrile
参考文献
Giardina; Grugni, Mario; Rigolio, Roberto; Vassallo, Marco; Erhard, Karl; Farina, Carlo
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2307 - 2310
参考文献
Sanofi
Patent: US5780466 A1, 1998 ;
US 5780466 A
反应条件
1: 80 percent / H2SO4 / acetonitrile 2: H2 / Pd/C / ethanol 3: TEA / dimethylformamide View Scheme
参考文献
Giardina; Grugni, Mario; Rigolio, Roberto; Vassallo, Marco; Erhard, Karl; Farina, Carlo
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2307 - 2310
反应条件
1: 80 percent / H2SO4 / acetonitrile
2: H2 / Pd/C / ethanol
3: TEA / dimethylformamide
4: 70 percent / KOH, TBAB / tetrahydrofuran / 24 h / 40 °C
View Scheme
参考文献
Giardina; Grugni, Mario; Rigolio, Roberto; Vassallo, Marco; Erhard, Karl; Farina, Carlo
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2307 - 2310
反应条件
phosphorus pentoxide in toluene
Heating;
参考文献
Sakamuri, Sukumar; Enyedy, Istvan J; Kozikowski, Alan P; Zaman, Wahiduz A; Johnson, Kenneth M; Wang, Shaomeng
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 495 - 500
反应条件
aluminium trichloride
T=50 - 55°C; 1 h; Yield given;
参考文献
Schaefer; Hackmack; Eistetter; Krueger; Menge; Klosa
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 3 p. 233 - 240
