4-甲基-N-(2-硝基苯基)苯磺酰胺合成路线 （共 13 条）
反应条件
1: NaOH-solution 2: glacial acetic acid; sulfuric acid / auf dem Wasserbad View Scheme
参考文献
Usherwood; Whiteley
Journal of the Chemical Society, 1923 , vol. 123, p. 1082
反应条件
1: 4-methyl-N-(2-nitrophenyl)benzenesulfonamide With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.25 h;
2: dimethyl sulfate in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1174028 A1, 2002 ;
Location in patent: Example 52 ;
反应条件
dimethyl sulfate in water; N,N-dimethyl-formamide
参考文献
Sumitomo Chemical Takeda Agro Company, Limited
Patent: US6586617 B1, 2003 ;
反应条件
1: sodium ethylate; ethanol
2: aqueous sulfuric acid
View Scheme
参考文献
King; Acheson
Journal of the Chemical Society, 1946 , p. 681,684
反应条件
pyridine in dichloromethane
T=20°C; 16 h;
参考文献
Alp, Cemalettin; Oezsoy, Seyda; Alp, Nurdan Alcan; Erdem, Deryanur; Gueltekin, Mehmet Serdar; Kuefrevioglu, Oemer Irfan; Sentuerk, Murat; Supuran, Claudiu T.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 6 p. 818 - 824
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20 - 50°C;
参考文献
Bunce, Richard A.; Smith, Christopher L.; Knight, Christopher L.
Organic Preparations and Procedures International, 2004 , vol. 36, # 5 p. 482 - 487
反应条件
pyridine
T=60°C; 12 h;
参考文献
Yasuhara, Akito; Kameda, Mitsuyoshi; Sakamoto, Takao
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 6 p. 809 - 812
反应条件
copper(l) iodide; 1,10-phenanthroline; Cu; potassium carbonate in N,N-dimethyl-formamide
T=110°C; 24 h;
参考文献
Yavari; Solgi; Ghazanfarpour-Darjani; Ahmadian
Journal of the Iranian Chemical Society, 2012 , vol. 9, # 6 p. 977 - 981
反应条件
potassium phosphate in N,N-dimethyl-formamide
T=150°C; 24 h; Inert atmosphere;
参考文献
Kato, Yuzo; Yen, Dinh Hoang; Fukudome, Yasuhiro; Hata, Takeshi; Urabe, Hirokazu
Organic Letters, 2010 , vol. 12, # 18 p. 4137 - 4139
反应条件
potassium phosphate in N,N-dimethyl-formamide
T=150°C; 8 h; Inert atmosphere;
参考文献
Kato, Yuzo; Yen, Dinh Hoang; Fukudome, Yasuhiro; Hata, Takeshi; Urabe, Hirokazu
Organic Letters, 2010 , vol. 12, # 18 p. 4137 - 4139
