3-甲基-2-丁烯酸乙酯合成路线 （共 160 条）
参考文献
Matsui et al.
Journal of Vitaminology, 1958 , vol. 4, p. 190,192
反应条件
1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran / 0.25 h / -78 °C / |Inert atmosphere 1.2: 1 h / -78 °C / |Inert atmosphere 2.1: lithium aluminium tetrahydride / diethyl ether / 1.33 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Pepper, Henry P.; Tulip, Stephen J.; Nakano, Yuji; George, Jonathan H.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2564 - 2573
反应条件
potassium carbonate in N,N-dimethyl-formamide T=130°C; 8 h;
参考文献
Kawase, Yoshiyuki; Yamaguchi, Seiji; Horita, Hisanori; Takeno, Junko; Kameyama, Hideaki
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 4 p. 1153 - 1155
反应条件
1.1: ammonia / ethanol / 16 h / -70 - 45 °C / 10343.2 Torr / Autoclave 1.2: 0.5 h / 0 °C / pH 2 / Inert atmosphere 2.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C 3.1: sodium ethanolate / toluene / 4 h / 80 °C 4.1: acetonitrile; water / 3 h / Reflux View Scheme
参考文献
AVILA THERAPEUTICS, INC.
Patent: US2011/230476 A1, 2011 ;
参考文献
Matsui et al.
Journal of Vitaminology, 1958 , vol. 4, p. 190,192
反应条件
eine vielleicht identische Verbindung entsteht, die nur als Semicarbazon (F: 124grad) isoliert wird;
参考文献
Courtot
Bulletin de la Societe Chimique de France, 1906 , vol. <3>35, p. 984
Full Text Show Details
Blaise; Courtot
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905 , vol. 140, p. 371
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C;
参考文献
Shrestha-Dawadi, Prativa Bade; Lugtenburg, Johan
European Journal of Organic Chemistry, 2003 , # 23 p. 4654 - 4663
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere 1.2: 2.5 h / 0 °C / |Inert atmosphere 2.1: lithium aluminium tetrahydride / diethyl ether / 1.17 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Pepper, Henry P.; Tulip, Stephen J.; Nakano, Yuji; George, Jonathan H.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2564 - 2573
反应条件
1: 89 percent / NH3(gas) / ethanol / 22 h / 80 °C 2: 81 percent / CH2Cl2 / 18 h View Scheme
参考文献
Thaisrivongs; Pals; DuCharme; Turner; DeGraaf; Lawson; Couch; Williams
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 633 - 642
反应条件
sodium hydroxide; tetramethyl-ammonium iodide in N,N-dimethyl-formamide 1.) -15 deg C, 3 d; 2.) 0 deg C, 3 d; 3.) 10 deg C, 3 d; 4.) room temperature, 120 d;
参考文献
Hanack, Michael; Auchter, Anneliese; Wunde, Christian; Stoll, Theodor
Liebigs Annalen der Chemie, 1989 , p. 853 - 858
