3-甲基-2-丁烯酸乙酯合成路线 （共 160 条）
参考文献
Bouveault; Wahl
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1900 , vol. 131, p. 687,748
Bulletin de la Societe Chimique de France, 1901 , vol. <3>25, p. 801
反应条件
1: 91 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C 2: 83 percent / HBr / CH2Cl2 / 1.5 h / 0 °C 3: 85 percent / nBuLi / tetrahydrofuran; hexane / -70 - 20 °C View Scheme
参考文献
Shrestha-Dawadi, Prativa Bade; Lugtenburg, Johan
European Journal of Organic Chemistry, 2003 , # 23 p. 4654 - 4663
反应条件
potassium carbonate in N,N-dimethyl-formamide T=130°C; 8 h;
参考文献
Kawase, Yoshiyuki; Yamaguchi, Seiji; Horita, Hisanori; Takeno, Junko; Kameyama, Hideaki
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 4 p. 1153 - 1155
反应条件
selenium(IV) oxide; perchloric acid; acetic anhydride in acetic acid T=40°C; 4 h;
参考文献
Kagabu; Shimizu; Ito; Moriya
Synthesis, 1992 , # 9 p. 830 - 832
反应条件
lithium hydroxide in ethanol; water T=20°C; 10 h; Inert atmosphere;
参考文献
Sharma, Vasudha; Kelly, Gilbert T.; Watanabe, Coran M. H.
Organic Letters, 2008 , vol. 10, # 21 p. 4815 - 4818
反应条件
1: 94 percent / LDA / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C -> room temperature, 1 h 2: 5percent NaOH / ethanol / 2 h / Heating 3: SOCl2 / 4 h 4: diethyl ether 5: 1.) boron trifluoride etherate, 2.) 10percent aq. HCl / 1.) CH3NO2, 0 deg C, 30 min, 2.) reflux, 1 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 103, p. 1996
反应条件
N-bromosuccinmide in tetrachloromethane 2 h; Heating;
参考文献
McDonald, Ian A.; Palfreyman, Michael G.; Jung, Michel; Bey, Philippe
Tetrahedron Letters, 1985 , vol. 26, # 34 p. 4091 - 4092
反应条件
manganese(IV) oxide; diisobutylaluminium hydride 1.) ether, -78 deg C, 30 min, 2.) ethylacetate, 6 h; Yield given. Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 105, # 12 p. 4033 - 4039
反应条件
ammonia in ethanol T=90°C; 24 h;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 2 p. 293 - 307
反应条件
1: 91 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C 2: 83 percent / HBr / CH2Cl2 / 1.5 h / 0 °C View Scheme
参考文献
Shrestha-Dawadi, Prativa Bade; Lugtenburg, Johan
European Journal of Organic Chemistry, 2003 , # 23 p. 4654 - 4663
