5-溴-1-乙基吡啶-2(1H)-酮合成路线 （共 7 条）
反应条件
1: 5-bromo-2-hydroxypyridine With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.5 h;
2: ethyl iodide in N,N-dimethyl-formamide
T=20°C;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; BRESSI, Jerome, C.; CHU, Shaosong; ERICKSON, Philip; KOMANDLA, Mallareddy; KWOK, Lily; LAWSON, John, D.; STAFFORD, Jeffrey, A.; WALLACE, Michael, B.; ZHANG, Zhiyuan; DAS, Sanjib
Patent: WO2010/19899 A1, 2010 ;
Location in patent: Page/Page column 214 ;
反应条件
potassium carbonate in dimethyl sulfoxide
T=15°C; 16 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: WO2006/59778 A1, 2006 ;
Location in patent: Page/Page column 48 ;
WO 2006/059778 A1
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide
T=10°C; 4 h;
参考文献
Shusherina, N.P.; Likhomanova, T.I.; Nikolaeva, S.N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 12 p. 1284 - 1286
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 12 p. 1662 - 1664
反应条件
potassium hydroxide in ethanol
6 h; Heating;
参考文献
Saidova, F. M.; Binchkauskas, V. Sh.; Khorev, S. G.; Enikeev, E. Ya.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 2 p. 353 - 357
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 413 - 417
反应条件
1,4-dioxane dibromide in 1,4-dioxane
T=10°C; 1 h;
参考文献
Shusherina, N.P.; Likhomanova, T.I.; Nikolaeva, S.N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 12 p. 1284 - 1286
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 12 p. 1662 - 1664
反应条件
1: 86 percent / bromine / acetic acid / 2 h / 20 °C
2: 1) conc. H2SO4, NaNO2; 2) H2O / 1) 0 deg. C, 2 h; 2) heating on a water bath
3: 53 percent / KOH (s) / ethanol / 6 h / Heating
View Scheme
参考文献
Saidova, F. M.; Binchkauskas, V. Sh.; Khorev, S. G.; Enikeev, E. Ya.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 2 p. 353 - 357
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 413 - 417
反应条件
1: 1) conc. H2SO4, NaNO2; 2) H2O / 1) 0 deg. C, 2 h; 2) heating on a water bath
2: 53 percent / KOH (s) / ethanol / 6 h / Heating
View Scheme
参考文献
Saidova, F. M.; Binchkauskas, V. Sh.; Khorev, S. G.; Enikeev, E. Ya.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 2 p. 353 - 357
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 413 - 417
