BOC-ALA-ALA-PRO-OH合成路线 （共 5 条）
反应条件
1: 72 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / -15 - 20 °C
2: 6.2N HCl / dioxane / 1 h
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
hydrogen; palladium on charcoal in ethanol; tert-butyl alcohol
参考文献
Merrell Pharmaceuticals Inc.
Patent: US5496927 A1, 1996 ;
反应条件
1: hydrogene / Pd-C / aq. NaOH
2: dioxane / 24 h
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: PyBOP, DIPEA / acetonitrile / -78 - 0 °C
2: 4 N HCl / dioxane
3: TBTU, DIPEA / acetonitrile / 0 °C
4: TBAF / tetrahydrofuran
View Scheme
参考文献
Hanessian, Stephen; Yang, Hua
Tetrahedron Letters, 1997 , vol. 38, # 18 p. 3155 - 3158
反应条件
in 1,4-dioxane
24 h;
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
