1-甲基-6-氧代-1,6-二氢吡啶-3-羧酸甲酯合成路线 （共 17 条）
反应条件
T=280°C; P=0.1 Torr; 24 h; Yield given;
参考文献
Newkome, George R.; Kohli, Dalip K.; Kawato, Toshio
Journal of Organic Chemistry, 1980 , vol. 45, # 22 p. 4508 - 4511
反应条件
N-bromosuccinmide in acetic acid T=80°C; 4 h;
参考文献
ONO PHARMACEUTICAL CO., LTD.
Patent: WO2007/40208 A1, 2007 ;
Location in patent: Page/Page column 159 ;
反应条件
potassium chloride in water T=25°C; Rate constant;
参考文献
Deady, Leslie W.
Australian Journal of Chemistry, 1985 , vol. 38, # 4 p. 637 - 641
反应条件
1: 2-hydroxy 5-pyridine carboxylic acid With sodium hydride in methanol
T=62°C;
2: methyl iodide in methanol
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259862 A1, 2007 ;
Location in patent: Page/Page column 29 ;
US 20070259862 A1
反应条件
1: 1,6-dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid With oxalyl dichloride in dichloromethane
0.5 h;
2: methanol in dichloromethane
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259862 A1, 2007 ;
Location in patent: Page/Page column 29 ;
US 20070259862 A1
反应条件
sodium hydroxide in chloroform
参考文献
Yu; Ruey J.; Van Scott; Eugene J.
Patent: US4258052 A1, 1981 ;
反应条件
1: 85 percent / silver carbonate / benzene / 96 h / 25 °C
2: 30 h / 280 °C
View Scheme
参考文献
Newkome, George R.; Kohli, Dalip K.; Kawato, Toshio
Journal of Organic Chemistry, 1980 , vol. 45, # 22 p. 4508 - 4511
反应条件
T=280°C; 30 h; Yield given. Further byproducts given. Yields of byproduct given;
参考文献
Newkome, George R.; Kohli, Dalip K.; Kawato, Toshio
Journal of Organic Chemistry, 1980 , vol. 45, # 22 p. 4508 - 4511
反应条件
T=280°C; 30 h; Yield given. Further byproducts given. Yields of byproduct given;
参考文献
Newkome, George R.; Kohli, Dalip K.; Kawato, Toshio
Journal of Organic Chemistry, 1980 , vol. 45, # 22 p. 4508 - 4511
反应条件
1: sodium methoxide / 3 h / Heating
2: thionyl chloride / 1.5 h / Heating
3: 0.5 h / Heating
View Scheme
参考文献
Deady, Leslie W.
Australian Journal of Chemistry, 1985 , vol. 38, # 4 p. 637 - 641
