2-氯-6-(4-甲基苯基)吡嗪合成路线 (共 2 条)
反应条件
trichlorophosphate in N,N-dimethyl-formamide; toluene
T=20°C; 20 h;
参考文献
Leclerc, Jean-Philippe; Fagnou, Keith
Angewandte Chemie - International Edition, 2006 , vol. 45, # 46 p. 7781 - 7786
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
18 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/762 A2, 2003 ;
Location in patent: Page 42 ;
WO 2004/000762 A2